Photoinitiated Multicomponent Anti-Markovnikov Alkoxylation over Graphene Oxide

被引：2

作者：

Nie, Liang ^{[1
]}

Peng, Xiangjun ^{[2
]}

He, Haiping ^{[2
]}

Hu, Jian ^{[2
]}

Yao, Zhiyang ^{[2
]}

Zhou, Linyi ^{[1
]}

Yang, Ming ^{[1
]}

Li, Fan ^{[1
]}

Huang, Qing ^{[1
]}

Liu, Liangxian ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Peoples R China

[2] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrov, Minist Educ, Ganzhou 341000, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 02期

基金：

中国国家自然科学基金;

关键词：

graphene oxide; anti-Markovnikov addition; quinoxalone; alkoxyl radical; CARBON MATERIAL; RADICALS; CARBOCATALYSIS; GENERATION; CATALYSIS; CHEMISTRY; SALTS;

D O I：

10.3390/molecules27020475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of graphene oxide-based heterogeneous materials with an economical and environmentally-friendly manner has the potential to facilitate many important organic transformations but proves to have few relevant reported reactions. Herein, we explore the synergistic role of catalytic systems driven by graphene oxide and visible light that form nucleophilic alkoxyl radical intermediates, which enable an anti-Markovnikov addition exclusively to the terminal alkenes, and then the produced benzyl radicals are subsequently added with N-methylquinoxalones. This photoinduced cascade radical difunctionalization of olefins offers a concise and applicable protocol for constructing alkoxyl-substituted N-methylquinoxalones.

引用

页数：13

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