An improved synthetic protocol and plausible mechanism in forming acetylpyridines from 2,6-dicarbethoxypyridine

被引：8

作者：

Asma, Maliha ^{[1
,2
,3
]}

Adewuyi, Sheriff ^{[1
,2
]}

Kuang, Xiaofei ^{[1
,2
]}

Badshah, Amin ^{[3
]}

Sun, Wen-Hua ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Engn Plast, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China

[3] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

来源：

LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 04期

关键词：

2-Carbethoxy-6-acetylpyridine; 2,6-diacetylpyridine; 2,6-dicarbethoxypyridine; Claisen ester condensation; anti-Claisen reaction;

D O I：

10.2174/157017808784049515

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Carbethoxy-6-acetylpyridine and 2,6-diacetylpyridine were transformed in good yields from the reaction of 2,6-dicarbethoxypyridine and EtOAc in the presence of sodium along with/without an equivalent of ethanol to sodium in toluene. The beta-keto esters, the intermediates in the transformation of beta-keto carboxylate into acetyl group, were isolated for understanding the plausible mechanism.

引用

页码：296 / 299

页数：4

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