Formation of ondansetron polymorphs

被引：7

作者：

Llácer, JM ^{[1
]}

Gallardo, V ^{[1
]}

Parera, A ^{[1
]}

Ruiz, MA ^{[1
]}

机构：

[1] Univ Granada, Dept Pharm & Pharmaceut Technol, E-18071 Granada, Spain

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 177卷 / 02期

关键词：

differential scanning calorimetry; H-1 nuclear magnetic resonance; infrared spectroscopy; ondansetron; polymorphism;

D O I：

10.1016/S0378-5173(98)00349-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We used differential scanning calorimetry, infrared spectrophotometry and H-1 nuclear magnetic resonance imaging to search for polymorphs of ondansetron. Samples were tested under different conditions of temperature, pulverization and pH, and in different solvents. The factors identified as able to cause the formation of polymorphs were heating to different temperatures for different times, and the use of ethanol and methanol as solvents. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：221 / 229

页数：9

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