Interleukin 18 gene variation and risk of acute myocardial infarction

被引：18

作者：

Koch, Werner ^{[1
]}

Wolferstetter, Hannah ^{[1
]}

Schatke, Anna ^{[1
]}

Schoemig, Albert ^{[1
,2
]}

Kastrati, Adnan ^{[1
]}

机构：

[1] Deutsch Herzzentrum Munich, D-80636 Munich, Germany

[2] Tech Univ Munich, Med Klin Rechts Isar, Munich, Germany

来源：

CYTOKINE | 2011年 / 56卷 / 03期

关键词：

IL-18; Acute myocardial infarction; Genetic risk; Haplotype; Case-control study; STRONG PREDICTOR; MEDIA THICKNESS; HEART-DISEASE; INFLAMMATION; ATHEROSCLEROSIS; ASSOCIATION; EXPRESSION; INTIMA; HAPLOTYPES; CYTOKINE;

D O I：

10.1016/j.cyto.2011.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin 18 is an important mediator of inflammation and has been associated with the development and aggravation of cardiovascular diseases. We report that common variation in the interleukin 18 gene is related to acute myocardial infarction, a frequent clinical manifestation of atherosclerosis and thrombosis in coronary arteries. In a population of European, mainly (90%) German, ancestry (2136 cases with acute myocardial infarction and 1211 controls), the association was based on specific alleles and haplo-types derived from a set of six tagging single nucleotide polymorphisms. The rs1946519-(G) under bar (located in the 5' upstream region), rs360717-(V) under bar (exon 1), rs5744241-(G) under bar (intron 1), rs1834481-(C) under bar (intron 3), and rs3882891-A (intron 5) alleles (P <= 0.039) and a haplotype ((GCGCAG) under bar haplotype; P=0.0028) containing the (GCGCA) under bar motif derived from these alleles were associated with an increased risk of AMI. Corresponding with this result, the complementary alleles (rs1946519-T, rs360717-T, rs5744241-A, rs1834481-(G) under bar, and rs3882891-(C) under bar) and a haplotype (TTAGC) under bar haplotype; P = 0.018) with the (TTAGC) under bar motif showed protective effects. Haplotypes not including the GCGCA or TTAGC motif were not related to AMI (P >= 0.22). These observations suggest that the interleukin 18 gene is a susceptibility locus for acute myocardial infarction, a finding of potential interest in the clinical practice. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：786 / 791

页数：6

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