Trends in Attention-Deficit/Hyperactivity Disorder Drug Consumption in Children and Adolescents in Slovenia from 2001 to 2012: A Drug Use Study from a National Perspective

被引:19
作者
Stuhec, Matej [1 ]
Locatelli, Igor [2 ]
Svab, Vesna [3 ]
机构
[1] Ormoz Psychiat Hosp, Dept Clin Pharm, Ptujska Cesta 33, Ormoz, Slovenia
[2] Univ Ljubljana, Fac Pharm, Ljubljana, Slovenia
[3] Univ Ljubljana, Fac Med, Dept Psychiat, Ljubljana, Slovenia
关键词
DEFICIT HYPERACTIVITY DISORDER; MEDICATIONS; PREVALENCE; ANTIDEPRESSANTS; ATOMOXETINE; ANXIOLYTICS; ADHD;
D O I
10.1089/cap.2014.0071
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: In most Eastern and Central European countries, except Germany, there is a lack of drug consumption studies for attention-deficit/hyperactivity disorder (ADHD). The main purpose of the present study was to present the pattern and the evolution of national ADHD drug consumption in Slovenia. Methods: The national consumption data for the period 2001-2012 and medication costs were obtained from the database of the Health Insurance Institute of Slovenia. A defined daily dose (DDD) per 1000 inhabitants per day and the total medication cost in euro were extracted. Only immediate-release methylphenidate (IR-MPH), methylphenidate-osmotic release oral delivery system (OROS-MPH) and atomoxetine (ATX) have been approved for ADHD in Slovenia and are included in this study. Amphetamines have not been available in Slovenia. Results: ADHD drug consumption increased in Slovenia from 0.0537 DDD/1000 inhabitants/day in 2001 to 0.0687 DDD/1000 inhabitants/day in 2006 and to 0.3076 DDD/1000 inhabitants/day in 2012. The rise was largely because of an increase in OROS-MPH consumption and increase in ATX consumption, whereas the consumption of IR-MPH decreased rapidly. During the study period, the total cost of the medicines increased 31-fold. From 2007 to 2010, the total cost of ADHD medicines increased 14-fold and from 2010 to 2012 the cost increased by 11.4% only. Conclusions: When new drugs are licensed in a jurisdiction, their prescription rates increase rapidly. The changes in the pattern of prescribing medicines are evident in Slovenia, primarily in the increase of OROS-MPH and ATX prescriptions and in the rapid decrease of IR-MPH prescriptions. Results indicate a need for appropriate interventions in Slovenia.
引用
收藏
页码:254 / 259
页数:6
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