Intranasal sumatriptan for migraine in children

被引：0
作者：
Goldman, Ran D. [1 ]
Meckler, Garth D. [1 ]
机构：
[1] PRETx Program, Washington, DC 20017 USA
来源：
CANADIAN FAMILY PHYSICIAN | 2015年 / 61卷 / 05期
关键词：
QUALITY-OF-LIFE; PEDIATRIC MIGRAINE; NASAL SPRAY; PHARMACOLOGICAL-TREATMENT; EMERGENCY-DEPARTMENT; DOUBLE-BLIND; ADOLESCENTS; PLACEBO; HEADACHE; TRIAL;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Question I am seeing more and more children and adolescents with headaches that can be defined as migraine headache. I have read about intranasal sumatriptan as an abortive therapy. Is this an effective treatment? Answer Acute migraine headache among children and adolescents is common and treatment is challenging. Intranasal sumatriptan is a safe and mostly effective option for children and adolescents. Currently the recommended dose is 20 mg for children who weigh more than 40 kg and 10 mg for children who weigh between 20 and 39 kg. Larger trials should be conducted to overcome the limitations of small sample sizes, potential low plasma concentration, and placebo effects witnessed in studies to date.
引用
收藏
页码：435 / 437
页数：3
相关论文
共 27 条
[11]   Clinical pharmacokinetics of intranasal sumatriptan [J].
Fuseau, E ;
Petricoul, O ;
Moore, KHP ;
Barrow, A ;
Ibbotson, T .
CLINICAL PHARMACOKINETICS, 2002, 41 (11) :801-811
[12]  
Gentile G, 2014, PHARMACOGENOMICS, V15, P1539, DOI [10.2217/PGS.14.104, 10.2217/pgs.14.104]
[13]   Intranasal Drug Delivery for Children with Acute Illness [J].
Goldman, Ran D. .
CURRENT DRUG THERAPY, 2006, 1 (01) :127-130
[14]  
Klein-Kremer A, 2007, ISR J EMERG MED, V7, P31
[15]   Practice parameter: Pharmacological treatment of migraine headache in children and adolescents - Report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society [J].
Lewis, D ;
Ashwal, S ;
Hershey, A ;
Hirtz, D ;
Yonker, M ;
Silberstein, S .
NEUROLOGY, 2004, 63 (12) :2215-2224
[16]   CHILDHOOD MIGRAINE IN GENERAL-PRACTICE - CLINICAL-FEATURES AND CHARACTERISTICS [J].
MORTIMER, MJ ;
KAY, J ;
JARON, A .
CEPHALALGIA, 1992, 12 (04) :238-243
[17]   Quality of life in paediatric migraine: characterization of age-related effects using PedsQL 4.0 [J].
Powers, SW ;
Patton, SR ;
Hommel, KA ;
Hershey, AD .
CEPHALALGIA, 2004, 24 (02) :120-127
[18]   Randomized Controlled Trial of Treatment Expectation and Intravenous Fluid in Pediatric Migraine [J].
Richer, Lawrence ;
Craig, William ;
Rowe, Brian .
HEADACHE, 2014, 54 (09) :1496-1505
[19]   Treatment of Children With Migraine in Emergency Departments: National Practice Variation Study [J].
Richer, Lawrence P. ;
Laycock, Keri ;
Millar, Kelly ;
Fitzpatrick, Eleanor ;
Khangura, Simi ;
Bhatt, Maala ;
Guimont, Chantal ;
Neto, Gina ;
Noseworthy, Steve ;
Siemens, Ron ;
Gouin, Serge ;
Rowe, Brian H. .
PEDIATRICS, 2010, 126 (01) :E150-E155
[20]   Pediatric Migraine: Abortive Management in the Emergency Department [J].
Sheridan, David C. ;
Spiro, David M. ;
Meckler, Garth D. .
HEADACHE, 2014, 54 (02) :235-245
123