Genome Mining of Pseudomonas Species: Diversity and Evolution of Metabolic and Biosynthetic Potential

被引：17

作者：

Alam, Khorshed ^{[1
]}

Islam, Md. Mahmudul ^{[2
]}

Li, Caiyun ^{[1
]}

Sultana, Sharmin ^{[3
]}

Zhong, Lin ^{[1
]}

Shen, Qiyao ^{[1
]}

Yu, Guangle ^{[1
]}

Hao, Jinfang ^{[1
]}

Zhang, Youming ^{[1
]}

Li, Ruijuan ^{[1
]}

Li, Aiying ^{[1
]}

机构：

[1] Shandong Univ, Helmholtz Inst Biotechnol, Helmholtz Int Lab Antiinfect, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China

[2] Rajshahi Univ, Rajshahi Inst Biosci RIB, Dept Microbiol, Rajshahi 6212, Bangladesh

[3] Univ Chittagong, Dept Microbiol, Chittagong 4331, Bangladesh

来源：

MOLECULES | 2021年 / 26卷 / 24期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Pseudomonas; genome mining; natural products; biosynthetic pathway; gene cluster; genome comparison; DISCOVERY; ANTIBIOTICS; CHEMISTRY; GENES; LOGIC; HOST;

D O I：

10.3390/molecules26247524

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbial genome sequencing has uncovered a myriad of natural products (NPs) that have yet to be explored. Bacteria in the genus Pseudomonas serve as pathogens, plant growth promoters, and therapeutically, industrially, and environmentally important microorganisms. Though most species of Pseudomonas have a large number of NP biosynthetic gene clusters (BGCs) in their genomes, it is difficult to link many of these BGCs with products under current laboratory conditions. In order to gain new insights into the diversity, distribution, and evolution of these BGCs in Pseudomonas for the discovery of unexplored NPs, we applied several bioinformatic programming approaches to characterize BGCs from Pseudomonas reference genome sequences available in public databases along with phylogenetic and genomic comparison. Our research revealed that most BGCs in the genomes of Pseudomonas species have a high diversity for NPs at the species and subspecies levels and built the correlation of species with BGC taxonomic ranges. These data will pave the way for the algorithmic detection of species- and subspecies-specific pathways for NP development.

引用

页数：17

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