Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation

被引：19

作者：

Bi, Decheng ^{[1
,2
]}

Lai, Qiuxian ^{[2
]}

Han, Qingguo ^{[2
]}

Cai, Nan ^{[2
]}

He, Hanxing ^{[2
]}

Fang, Weishan ^{[3
]}

Yi, Jiang ^{[4
]}

Li, Xiaofan ^{[2
]}

Xu, Hong ^{[2
]}

Li, Xiuting ^{[1
]}

Hu, Zhangli ^{[2
]}

Liu, Qiong ^{[2
]}

Xu, Xu ^{[2
]}

机构：

[1] BTBU, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100000, Peoples R China

[2] Shenzhen Univ, Shenzhen Key Lab Marine Bioresources & Ecol, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China

[3] Shenzhen Univ, Sch Med, Shenzhen 518055, Peoples R China

[4] Shenzhen Univ, Dept Food Sci & Technol, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 51卷

基金：

中国国家自然科学基金;

关键词：

Seleno-polymannuronate; Primary microglia; Primary astrocytes; Anti-neuroinflammation; ANTIOXIDANT ACTIVITY; NITRIC-OXIDE; ALGINATE; OLIGOSACCHARIDES; POLYSACCHARIDE; DISEASE; PHAGOCYTOSIS; KINASE; ALPHA; CELLS;

D O I：

10.1016/j.jff.2018.10.010

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Polymannuronate (PM) is an acidic polymer separated from alginate. PM is a linear block polysaccharide in edible brown algae that has been widely used in the food industry. Seleno-polymannuronate (Se-PM) is a seleno-derivative of PM synthesized from PM and Na2SO3 in our laboratory. We investigated the anti-neuroinflammatory activity of Se-PM in lipopolysaccharide (LPS)-activated primary microglia and astrocytes and a mouse model of acute inflammation. Our results show that Se-PM could markedly reduce NO and PGE(2) production, iNOS and COX-2 expression, and TNF-alpha, IL-1 beta and IL-6 secretion in LPS-treated primary microglia and astrocytes. Moreover, the LPS-triggered overactivation of NF-kappa B and MAPK signalling was attenuated by Se-PM. In addition, in vivo, LPS-induced microglial and astrocytic activation was remarkably suppressed by Se-PM. These results suggest that Se-PM merits exploration as an alternative medicinal or functional food for alleviating neuroinflammation.

引用

页码：113 / 120

页数：8

共 38 条

[1]

Beardsley PM, 2014, ADV PHARMACOL, V69, P1, DOI 10.1016/B978-0-12-420118-7.00001-9

[2] Elucidation of the Molecular-Mechanisms and In Vivo Evaluation of the Anti-inflammatory Effect of Alginate-Derived Seleno-polymannuronate [J].

Bi, Decheng ;

Lai, Qiuxian ;

Cai, Nan ;

Li, Tong ;

Zhang, Yiyao ;

Han, Qingguo ;

Peng, Yanwen ;

Xu, Hong ;

Lu, Jun ;

Bao, Weiyang ;

Liu, Qiong ;

Xu, Xu .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66 (09) :2083-2091

[3] Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages [J].

Bi, Decheng ;

Zhou, Rui ;

Cai, Nan ;

Lai, Qiuxian ;

Han, Qingguo ;

Peng, Yanwen ;

Jiang, Zedong ;

Tang, Zhishu ;

Lu, Jun ;

Bao, Weiyang ;

Xu, Hong ;

Xu, Xu .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 105 :1446-1454

[4] Neuroinflammation in Alzheimer's disease: Current evidence and future directions [J].

Calsolaro, Valeria ;

Edison, Paul .

ALZHEIMERS & DEMENTIA, 2016, 12 (06) :719-732

[5] Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain [J].

Carrero, I. ;

Gonzalo, M. R. ;

Martin, B. ;

Sanz-Anquela, J. M. ;

Arevalo-Serrano, J. ;

Gonzalo-Ruiz, A. .

EXPERIMENTAL NEUROLOGY, 2012, 236 (02) :215-227

[6] Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages [J].

Fang, Weishan ;

Bi, Decheng ;

Zheng, Ruijin ;

Cai, Nan ;

Xu, Hong ;

Zhou, Rui ;

Lu, Jun ;

Wan, Min ;

Xu, Xu .

SCIENTIFIC REPORTS, 2017, 7

[7] Selenium in health and disease: A review [J].

Foster, LH ;

Sumar, S .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 1997, 37 (03) :211-228

[8] Selenium level and cognitive function in rural elderly Chinese [J].

Gao, Sujuan ;

Jin, Yinlong ;

Hall, Kathleen S. ;

Liang, Chaoke ;

Unverzagt, Frederick W. ;

Ji, Rongdi ;

Murrell, Jill R. ;

Cao, Jingxiang ;

Shen, Jianzhao ;

Ma, Feng ;

Matesan, Janetta ;

Ying, Bo ;

Cheng, Yibin ;

Bian, Jianchao ;

Li, Ping ;

Hendrie, Hugh C. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 165 (08) :955-965

[9] Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia [J].

Han, Jung Eun ;

Choi, Ji Woong .

ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (04) :709-715

[10] STUDIES ON SEQUENCE OF URONIC ACID RESIDUES IN ALGINIC ACID [J].

HAUG, A ;

LARSEN, B ;

SMIDSROD, O .

ACTA CHEMICA SCANDINAVICA, 1967, 21 (03) :691-&

← 1 2 3 4 →