Malaria in pregnancy: the relevance of animal models for vaccine development

被引：15

作者：

Doritchamou, Justin ^{[1
]}

Teo, Andrew ^{[1
]}

Fried, Michal ^{[1
]}

Duffy, Patrick E. ^{[1
]}

机构：

[1] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD 20857 USA

来源：

LAB ANIMAL | 2017年 / 46卷 / 10期

基金：

美国国家卫生研究院;

关键词：

FALCIPARUM-INFECTED ERYTHROCYTES; PLASMODIUM-VIVAX MALARIA; CHONDROITIN-SULFATE-A; FETAL-GROWTH RESTRICTION; DEEP VASCULAR SCHIZOGONY; PLACENTAL MALARIA; ANTIGENIC VARIATION; MACACA-MULATTA; RHESUS-MONKEY; PARASITIZED ERYTHROCYTES;

D O I：

10.1038/laban.1349

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Malaria during pregnancy due to Plasmodium falciparum or P. vivax is a major public health problem in endemic areas, with P. falciparum causing the greatest burden of disease. I Increasing resistance of parasites and mosquitoes to existing tools, such as preventive antimalarial treatments and insecticide-treated bed nets respectively, is eroding the partial protection that they offer to pregnant women. Thus, development of effective vaccines against malaria during pregnancy is an urgent priority. Relevant animal models that recapitulate key features of the pathophysiology and immunology of malaria in pregnant women could be used to accelerate vaccine development. T This review summarizes available rodent and nonhuman primate models of malaria in pregnancy, and discusses their suitability for studies of biologics intended to prevent or treat malaria in this vulnerable population.

引用

页码：388 / 398

页数：11

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