Hybrid localized surface plasmon resonance and quartz crystal microbalance sensor for label free biosensing

被引：22

作者：

Hao, Danni ^{[1
]}

Hu, Chunxiao ^{[1
]}

Grant, James ^{[1
]}

Glidle, Andrew ^{[1
]}

Cumming, David R. S. ^{[1
]}

机构：

[1] Univ Glasgow, Sch Engn, Rankine Bldg, Glasgow G12 8LT, Lanark, Scotland

来源：

BIOSENSORS & BIOELECTRONICS | 2018年 / 100卷

基金：

英国工程与自然科学研究理事会;

关键词：

LSPR; QCM; Point-of-care; SPECTROSCOPY; FREQUENCY; GLYCEROL; LIQUIDS; SYSTEMS; LAYERS; QCM; SPR;

D O I：

10.1016/j.bios.2017.08.038

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.

引用

页码：23 / 27

页数：5

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