The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer

被引：41
作者：
Klos, Patrycja [1 ]
Dabravolski, Siarhei A. [2 ]
机构：
[1] Pomeranian Med Univ, Dept Biochem & Med Chem, 72 Al Powstancow Wlkp, PL-70111 Szczecin, Poland
[2] Vitebsk State Acad Vet Med UO VGAVM, Dept Clin Diagnost, 7-11 Dovatora Str, Vitebsk 210026, BELARUS
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期
关键词：
inflammatory bowel diseases; colorectal cancer; chronic inflammation; mitochondrial dysfunction; mitochondrial mutations; D-LOOP REGION; DIFFERENTIAL EXPRESSION; CLINICAL-SIGNIFICANCE; RISK; POLYMORPHISMS; PATHOGENESIS; PGC-1-ALPHA; CHAPERONE; CELLS; DNA;
D O I：
10.3390/ijms222111673
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease-colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed.
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页数：19
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