Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria

被引：66

作者：

Guo, Diliang ^{[2
,3
]}

Chen, Tao ^{[1
]}

Ye, Deju ^{[2
]}

Xu, Jinyi ^{[3
]}

Jiang, Hualiang ^{[2
]}

Chen, Kaixian ^{[2
,3
]}

Wang, Hui ^{[1
]}

Liu, Hong ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China

[3] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 11期

基金：

中国国家自然科学基金;

关键词：

PHASE SYNTHESIS; PROBES; FLUOROPHORES; DISCOVERY; ARYLATION;

D O I：

10.1021/ol200908r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A class of small molecule fluorophores, 2-iminocoumarin-3-carboxamide derivatives, has been developed by a rapid microwave-assisted process. These fluorescent probes are cell membrane permeable with low cytotoxicity and able to selectively stain organelles in living cells.

引用

页码：2884 / 2887

页数：4

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