Correlated gene expression supports synchronous activity in brain networks

被引：446

作者：

Richiardi, Jonas ^{[1
,2
]}

Altmann, Andre ^{[1
]}

Milazzo, Anna-Clare ^{[1
,3
]}

Chang, Catie ^{[4
]}

Chakravarty, M. Mallar ^{[5
,6
,7
]}

Banaschewski, Tobias ^{[8
]}

Barker, Gareth J. ^{[9
]}

Bokde, Arun L. W. ^{[10
]}

Bromberg, Uli ^{[11
]}

Buechel, Christian ^{[11
]}

Conrod, Patricia ^{[9
,12
]}

Fauth-Buehler, Mira ^{[13
]}

Flor, Herta ^{[14
]}

Frouin, Vincent ^{[15
]}

Gallinat, Juergen ^{[16
]}

Garavan, Hugh ^{[10
,17
,18
]}

Gowland, Penny ^{[19
]}

Heinz, Andreas ^{[16
]}

Lemaitre, Herve ^{[20
,21
]}

Mann, Karl F. ^{[13
]}

Martinot, Jean-Luc ^{[20
,21
]}

Nees, Frauke ^{[14
]}

Paus, Tomas ^{[22
,23
]}

Pausova, Zdenka ^{[24
]}

Rietschel, Marcella ^{[25
]}

Robbins, Trevor W. ^{[26
,27
]}

Smolka, Michael N. ^{[28
,29
]}

Spanagel, Rainer ^{[30
]}

Stroehle, Andreas ^{[16
]}

Schumann, Gunter ^{[9
,31
]}

Hawrylycz, Mike ^{[32
]}

Poline, Jean-Baptiste ^{[33
]}

Greicius, Michael D. ^{[1
]}

机构：

[1] Stanford Univ, Dept Neurol & Neurol Sci, Funct Imaging Neuropsychiat Disorders Lab, Stanford, CA 94305 USA

[2] Univ Geneva, Dept Neurosci, Lab Neurol & Imaging Cognit, Geneva, Switzerland

[3] VA Palo Alto Hlth Care Syst, War Related Illness & Injury Study Ctr, Palo Alto, CA USA

[4] NINDS, Adv MRI Sect, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA

[5] Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ, Canada

[6] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[7] McGill Univ, Dept Biomed Engn, Montreal, PQ, Canada

[8] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat, Mannheim, Germany

[9] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[10] Trinity Coll Dublin, Inst Neurosci, Dublin, Ireland

[11] Univ Klinikum Hamburg Eppendorf, Hamburg, Germany

[12] Univ Montreal, Dept Psychiat, Ctr Hosp Univ CHU, Ste Justine Hosp, Montreal, PQ H3C 3J7, Canada

[13] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany

[14] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, Mannheim, Germany

[15] Commissariat Energie Atom & Energies Alternat, Neurospin, Paris, France

[16] Charite, Campus Charite Mitte, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany

[17] Univ Vermont, Dept Psychiat, Burlington, VT USA

[18] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA

[19] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England

[20] Univ Paris Sud, INSERM, U1000, Neuroimaging & Psychiat, F-91405 Orsay, France

[21] Univ Paris 05, Cochin Hosp, APHP, INSERM,U1000,Maison Solenn,Sorbonne Paris Cite, Paris, France

[22] Univ Toronto, Rotman Res Inst, Toronto, ON, Canada

[23] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England

[24] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[25] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany

[26] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England

[27] Univ Cambridge, Dept Psychol, Cambridge, England

[28] Tech Univ Dresden, Dept Psychiat & Psychotherapy, D-01062 Dresden, Germany

[29] Tech Univ Dresden, Neuroimaging Ctr, D-01062 Dresden, Germany

[30] Fac Clin Med Mannheim, Cent Inst Mental Hlth, Dept Psychopharmacol, Mannheim, Germany

[31] MRC, Social Genet & Dev Psychiat SGDP Ctr, London, England

[32] Allen Inst Brain Sci, Seattle, WA USA

[33] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

SCIENCE | 2015年 / 348卷 / 6240期

基金：

美国国家卫生研究院; 英国医学研究理事会; 英国惠康基金;

关键词：

RESTING STATE NETWORKS; MOUSE-BRAIN; TRANSCRIPTOME; CONNECTIVITY; ATLAS;

D O I：

10.1126/science.1255905

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

引用

页码：1241 / 1244

页数：4

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