Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects

被引：147
作者：
Gonzalez-Sarrias, Antonio [1 ]
Carlos Espin, Juan [1 ]
Tomas-Barberan, Francisco A. [1 ]
机构：
[1] CEBAS CSIC, Res Grp Qual Safety & Bioact Plant Foods, Food & Hlth Lab, POB 164,30100 Campus Espinardo, Murcia, Spain
来源：
TRENDS IN FOOD SCIENCE & TECHNOLOGY | 2017年 / 69卷
关键词：
Macroantioxidants; Gut microbiota metabolites; Anti-inflammatory; Antioxidant; Proanthocyanidin; Ellagitannin; URINARY-EXCRETION; ELLAGIC ACID; PHENOLIC-ACIDS; ELLAGITANNIN METABOLITES; INTESTINAL MICROBIOTA; ORANGE JUICE; ANTIOXIDANT; BIOAVAILABILITY; UROLITHINS; HESPERETIN;
D O I：
10.1016/j.tifs.2017.07.010
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Recent studies demonstrate that fruits are rich in non-extractable polyphenols, macro-antioxidants, which have been underestimated. These are not absorbed and reach the colon where are catabolized by human gut microbiota releasing low molecular weight phenolics that are then absorbed efficiently. These metabolites persist in human plasma for extended times up to 3-4 days after the intake with significant concentrations. Preclinical studies with these metabolites at the concentrations that can be reached in plasma have reported anti-inflammatory and anti-oxidant effects that could be related to health benefits observed in vivo after the intake of the non-extractable macro-antioxidants. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：281 / 288
页数：8
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