Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients

被引：20

作者：

Wang, Yu-Qin ^{[1
]}

Dai, Xiao-Dan ^{[1
]}

Ran, Yun ^{[1
]}

Cao, Ying ^{[1
]}

Lan, Chun-Lin ^{[1
]}

Guan, Ji-Tian ^{[1
]}

Liu, Chang ^{[1
]}

Yang, Feng-Mei ^{[1
]}

Gan, Yi-Jing ^{[1
]}

Liu, Bai-Jing ^{[1
]}

Fang, Ai-Wu ^{[1
]}

Lin, Dan ^{[1
]}

Gong, Xian-Hui ^{[1
]}

Cui, Ren-Zhe ^{[2
]}

Jin, Zi-Bing ^{[1
]}

Qu, Jia ^{[1
]}

Lu, Fan ^{[1
]}

Chi, Zai-Long ^{[1
]}

机构：

[1] Wenzhou Med Univ, State Key Lab Ophthalmol Optometry & Visual Sci, Hosp Eye, 270 West Xueyuan Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Yanbian Univ, Dept Ophthalmol, Affiliated Hosp, Yanji, Jilin, Peoples R China

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2020年 / 28卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Biomarker; calprotectin; ocular inflammation; A9; uveitis; FECAL CALPROTECTIN; DISEASE-ACTIVITY; BIOMARKER; PROTEIN; SERUM; S100A8/S100A9; ACTIVATION; ARTHRITIS; MRP14;

D O I：

10.1080/09273948.2018.1538461

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values. Conclusion: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.

引用

页码：133 / 141

页数：9

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