Nickel-catalyzed transfer hydrogenation of ketones using ethanol as a solvent and a hydrogen donor

被引：69

作者：

Castellanos-Blanco, Nahury ^{[1
]}

Arevalo, Alma ^{[1
]}

Garcia, Juventino J. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Ciudad Univ, Mexico City 04510, DF, Mexico

来源：

DALTON TRANSACTIONS | 2016年 / 45卷 / 34期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; RHODIUM(III) COMPLEXES; RUTHENIUM COMPLEXES; IRON(II) COMPLEXES; CARBONYL-COMPOUNDS; IRIDIUM COMPLEXES; ACETOPHENONE; LIGANDS; WATER; COORDINATION;

D O I：

10.1039/c6dt02725c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report a nickel(0)-catalyzed direct transfer hydrogenation (TH) of a variety of alkyl-aryl, diaryl, and aliphatic ketones with ethanol. This protocol implies a reaction in which a primary alcohol serves as a hydrogen atom source and solvent in a one-pot reaction without any added base. The catalytic activity of the nickel complex [(dcype)Ni(COD)] (e) (dcype: 1,2-bis(dicyclohexyl-phosphine) ethane, COD: 1,5-cycloocta-diene), towards transfer hydrogenation (TH) of carbonyl compounds using ethanol as the hydrogen donor was assessed using a broad scope of ketones, giving excellent results (up to 99% yield) compared to other homogeneous phosphine-nickel catalysts. Control experiments and a mercury poisoning experiment support a homogeneous catalytic system; the yield of the secondary alcohols formed in the TH reaction was monitored by gas chromatography (GC) and NMR spectroscopy.

引用

页码：13604 / 13614

页数：11

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