Lanostane triterpenoids from the medicinal mushroom Ganoderma tsugae

被引：1

作者：

Wu, Chien-Ming ^{[1
,2
]}

Lin, Chun-Nan ^{[1
]}

Chen, Hui-Chia ^{[3
]}

Chang, Shin C. ^{[3
]}

Chang, Ming-Fu ^{[4
]}

Lin, Kai-Wei ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Kaohsiung 80708, Taiwan

[2] Yuans Gen Hosp, Dept Phys Med & Rehabil, Kaohsiung 80249, Taiwan

[3] Natl Taiwan Univ, Grad Inst Microbiol, Coll Med, Taipei 10051, Taiwan

[4] Natl Taiwan Univ, Coll Med, Biochem & Mol Biol, Taipei 10051, Taiwan

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 51卷

关键词：

Ganoderma tsugae; Stereochemistry; Lanostanoids; LC-ESI-MS; HCV; HEPATITIS-C VIRUS; STEROIDS;

D O I：

10.1016/j.phytol.2022.08.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two undescribed lanostane triterpenoids, tsugaric acids G (1) and H (2), and a known compound, N-(3';alpha,4';beta-dihydroxy-2';beta-(hydroxymethyl)-1';beta-(cyclobutyl) palmitamide (3) were isolated from the fruiting bodies of Ganoderma tsugae and characterized on the basis of spectroscopic and spectrometric analysis, especially 2D NMR and HRMS. Compounds 1 and 2 were also characterized by an LC-ESI-MS analytical approach and were compared with the fragmentation patterns of reported compounds. Compound 3 significantly exhibited anti-HCV activity.

引用

页码：114 / 118

页数：5

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