BMIM[BF4]: An Efficient Ionic Liquid Medium for the Synthesis of Chromeno[b]pyridines as Potential Anticancer Agents

被引：2
作者：
Kalpana, K. [1 ]
Rani, V. A. [2 ]
Seshadri, S. [3 ]
Kiran, B. Ravi [1 ]
机构：
[1] Gokaraju Rangaraju Inst Engn & Technol, Dept Humanities & Sci Chem, Hyderabad 500090, India
[2] Inst Aeronaut Engn, Dept Chem, Hyderabad 500043, India
[3] Nirma Univ, Inst Sci, Ahmadabad 382470, Gujarat, India
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 09期
关键词：
green synthesis; one-pot reaction; anticancer activity; molecular descriptors prediction; chromeno[4; 3-b]pyridines; DERIVATIVES;
D O I：
10.1134/S1070428021090177
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-amino-4-aryl-5-oxochromeno[4,3-b]pyridine-3-carbonitriles have been synthesized with good yields (85-90%) by reacting 4-amino-2H-chromen-2-one, substituted benzaldehydes, and malono-nitrile at 80-85 degrees C for 90-120 min using 1-butyl-3-methylimidazolium tetrafluoroborate as an ionic liquid medium. The synthesized derivatives have been screened for their anticancer potential on SKOV-3 and PC-3 cell lines, and the results were found to be encouraging. In addition, molecular descriptor prediction was performed for the compounds in terms of Lipinski's rule of five; in particular, their topological polar surface areas (TPSA) and lipophilicities (iLogP) were found to be within an acceptable range.
引用
收藏
页码：1501 / 1507
页数：7
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