FosB, a cysteine-dependent fosfomycin resistance protein under the control of σW, an extracytoplasmic-function σ factor in Bacillus subtilis

被引：113

作者：

Cao, M

Bernat, BA

Wang, ZP

Armstrong, RN

Helmann, JD ^{[1
]}

机构：

[1] Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA

[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA

来源：

JOURNAL OF BACTERIOLOGY | 2001年 / 183卷 / 07期

关键词：

D O I：

10.1128/JB.183.7.2380-2383.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires sigma (W), and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn2+-dependent glutathione transferases but with a preference for Mg2+ and L-cysteine as cofactors.

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页码：2380 / 2383

页数：4

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