Quantitation of homogentisic acid in normal human plasma

被引：18

作者：

Deutsch, JC ^{[1
]}

SanthoshKumar, CR ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DIV HEMATOL,DENVER,CO 80220

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1996年 / 677卷 / 01期

关键词：

homogentisic acid;

D O I：

10.1016/0378-4347(95)00442-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new stable isotope dilution gas chromatograph-mass spectrometric method of analysis of homogentisic acid is described. Using this method, homogentisic acid is measured for the first time in normal human plasma. The assay of sera from nine normal individuals yielded a range of values from 2.4 to 12 ng/ml. The method appears to be very sensitive and may be useful in the characterization of heterozygotes for alkaptonuria and other disorders of tyrosine degradation.

引用

页码：147 / 151

页数：5

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