Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells

被引：33
作者：
Opitz, Christiane A.
Rimmerman, Neta
Zhang, Yanmin
Mead, Laura E.
Yoder, Mervin C.
Ingram, David A.
Walker, J. Michael
Rehman, Jalees
机构：
[1] Indiana Univ, Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Dept Psychol & Brain Sci, Gill Ctr Biomol Sci, Bloomington, IN 47405 USA
[3] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN USA
来源：
FEBS LETTERS | 2007年 / 581卷 / 25期
关键词：
endothelium-derived factor; inflammation; endothelium; endothelial progenitor cell; endocannabinoid;
D O I：
10.1016/j.febslet.2007.09.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies have highlighted the importance of paracrine growth factors as mediators of pro-angiogenic effects by endothelial progenitor cells (EPCs), but little is known about the release of lipid-based factors like endocannabinoids by EPCs. In the current study, the release of the endocannabinoids anandamide and 2-arachidonoylglycerol by distinct human EPC sub-types was measured using HPLC/tandem mass-spectrometry. Anandamide release was highest by adult blood colony-forming EPCs at baseline and they also demonstrated increased 2-arachidonoylglycerol release with TNF-cx stimulation. Treatment of mature endothelial cells with endocannabinoids significantly reduced the induction of the pro-inflammatory adhesion molecule CD106 (VCAM-1) by TNF-alpha. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：4927 / 4931
页数：5
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