Novel Transgenic Mouse Model of Polycystic Kidney Disease

被引：7
|
作者：
Kito, Yusuke [1 ]
Saigo, Chiemi [1 ]
Takeuchi, Tamotsu [1 ]
机构：
[1] Gifu Univ, Grad Sch Med, Dept Pathol & Translat Res, Yanagido 1-1, Gifu 5011194, Japan
来源：
AMERICAN JOURNAL OF PATHOLOGY | 2017年 / 187卷 / 09期
基金：
日本学术振兴会;
关键词：
INTESTINAL TREFOIL FACTOR; CELL-CARCINOMA; EXPRESSION; MITF; REGULATOR; PROTEINS;
D O I：
10.1016/j.ajpath.2017.05.002
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Transmembrane protein 207 (TMEM207) is characterized as an important molecule for invasiveness of gastric signet-ring cell carcinoma cells. To clarify the pathobiological effects of TMEM207, we generated 13 transgenic mouse strains, designated C57BL/6-transgenic (Tg) (ITF-TMEM207), where the mouse Tmem207 is ectopically expressed under the proximal promoter of the murine intestinal trefoil factor gene. A C57BL/6-Tg (ITT-TMEM207) mouse strain unexpectedly exhibited a high incidence of spontaneous kidney cysts with histopathological features resembling human polycystic kidney disease, which were found in approximately all mice within 1 year. TMEM207 immunoreactivity was found in noncystic kidney tubules and in renal cysts of the transgenic mice. The ITF-TMEM207 construct was inserted into Mitf at chromosome 6. Cystic kidney was not observed in other C57BL/6-Tg (ITF-TMEM207) transgenic mouse strains. Although several genetically manipulated animal models exist, this mouse strain harboring a genetic mutation in Mitf and overexpression of Tmem207 protein was not reported as a model of polycystic kidney disease until now. This study demonstrates that the C57BL/6-Tg (ITF-TMEM207) mouse may be a suitable model for understanding human polycystic kidney disease.
引用
收藏
页码：1916 / 1922
页数：7
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