Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis

被引：29

作者：

Mori, H

Kawabata, K

Matsunaga, K

Ushida, J

Fujii, K

Hara, A

Tanaka, T

Murai, H

机构：

[1] Gifu Univ, Sch Med, Dept Pathol, Gifu 5008705, Japan

[2] Kanazawa Med Univ, Dept Pathol, Kanazawa, Ishikawa, Japan

[3] Oryza Oil & Fat Chem Co, Aichi, Japan

来源：

BIOFACTORS | 2000年 / 12卷 / 1-4期

关键词：

chlorogenic acid; ferulic acid; coffee; rice; colorectal carcinogenesis;

D O I：

10.1002/biof.5520120116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and gamma -aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans acid rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers.

引用

页码：101 / 105

页数：5

共 12 条

[1]

[Anonymous], J NUTR GROWTH CANC

[2] STUDY OF THE CAUSES OF DIRECT-ACTING MUTAGENICITY IN COFFEE AND TEA USING THE ARA TEST IN SALMONELLA-TYPHIMURIUM [J].

ARIZA, RR ;

DORADO, G ;

BARBANCHO, M ;

PUEYO, C .

MUTATION RESEARCH, 1988, 201 (01) :89-96

[3]

BARON JA, 1994, CANCER EPIDEM BIOMAR, V3, P565

[4]

KASAI H, IN PRESS FOOD CHEM T

[5]

KAWAMORI T, 1995, CANCER RES, V55, P1277

[6] Control of cell proliferation in cancer prevention [J].

Mori, H ;

Sugie, S ;

Yoshimi, N ;

Hara, A ;

Tanaka, T .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1999, 428 (1-2) :291-298

[7] INHIBITORY EFFECT OF CHLOROGENIC ACID ON METHYLAZOXYMETHANOL ACETATE-INDUCED CARCINOGENESIS IN LARGE-INTESTINE AND LIVER OF HAMSTERS [J].

MORI, H ;

TANAKA, T ;

SHIMA, H ;

ASU, TK ;

TAKAHASHI, M .

CANCER LETTERS, 1986, 30 (01) :49-54

[8]

Mori H, 1996, ENV MUTAGEN RES, V18, P73

[9]

NAGAO M, 1979, MUTAT RES, V68, P101, DOI 10.1016/0165-1218(79)90137-X

[10] THE RISKS OF CANCERS OF THE COLON AND RECTUM IN RELATION TO COFFEE CONSUMPTION [J].

ROSENBERG, L ;

WERLER, MM ;

PALMER, JR ;

KAUFMAN, DW ;

WARSHAUER, ME ;

STOLLEY, PD ;

SHAPIRO, S .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 130 (05) :895-903

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