Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients

被引：62

作者：

Holm, T ^{[1
]}

Andreassen, AK

Ueland, T

Kjekshus, J

Froland, SS

Kjekshus, E

Simonsen, S

Aukrust, P

Gullestad, L

机构：

[1] Univ Oslo, Rikshosp, Dept Cardiol, Internal Med Res Inst, N-0027 Oslo, Norway

[2] Univ Oslo, Rikshosp, Dept Med, Sect Clin Immunol & Infect Dis, N-0027 Oslo, Norway

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 06期

关键词：

D O I：

10.1016/S0002-9149(00)01516-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins appear to have several biologic effects beyond those of lipid metabolism, and we hypothesized that immunomodulating effects of statins are important for the beneficial effects of these medications after heart transplantation. Our findings suggest that pravastatin treatment reduces plasma markers of inflammation and improves peripheral endothelial function in heart transplant recipients, possibly contributing to the observed clinical benefits of statin treatment in these patients.

引用

页码：815 / +

页数：5

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