A silver bullet for the treatment of depression?

被引：29
作者：
Duman, Ronald S.
机构：
[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA
[2] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06508 USA
来源：
NEURON | 2007年 / 55卷 / 05期
关键词：
D O I：
10.1016/j.neuron.2007.08.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The search for a rapid-acting antidepressant has been a subject of intense research interest for several decades. The article by Lucas and colleagues in this issue of Neuron provides compelling evidence from preclinical animal models that drugs acting at the serotonin 5-HT4 receptor could finally achieve this goal. However, caution is warranted, as results from animal studies are not always predictive of therapeutic actions in humans.
引用
收藏
页码：679 / 681
页数：3
相关论文
共 12 条
[1]   New approaches to antidepressant drug discovery: beyond monoamines [J].
Berton, O ;
Nestler, EJ .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (02) :137-151
[2]   CURRENT ADVANCES AND TRENDS IN THE TREATMENT OF DEPRESSION [J].
BLIER, P ;
DEMONTIGNY, C .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) :220-226
[3]   The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound [J].
Briejer, MR ;
Bosmans, JP ;
Van Daele, P ;
Jurzak, M ;
Heylen, L ;
Leysen, JE ;
Prins, NH ;
Schuurkes, JAJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 423 (01) :71-83
[4]  
Duman RS, 1997, ARCH GEN PSYCHIAT, V54, P597
[5]   PHARMACOLOGICAL CHARACTERIZATION OF 2 NOVEL AND POTENT 5-HT4 RECEPTOR AGONISTS, RS-67333 AND RS-67506, IN-VITRO AND IN-VIVO [J].
EGLEN, RM ;
BONHAUS, DW ;
JOHNSON, LG ;
LEUNG, E ;
CLARK, RD .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (08) :1387-1392
[6]  
Haddjeri N, 1998, J NEUROSCI, V18, P10150
[7]   Peripheral 5-HT4 receptors [J].
Hegde, SS ;
Eglen, RM .
FASEB JOURNAL, 1996, 10 (12) :1398-1407
[8]   Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors [J].
Lamirault, L ;
Simon, H .
NEUROPHARMACOLOGY, 2001, 41 (07) :844-853
[9]   Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity:: Viral transfections, subacute and chronic treatments with 5-HT4 agonists [J].
Lucas, G ;
Compan, V ;
Charnay, Y ;
Neve, RL ;
Nestler, EJ ;
Bockaert, J ;
Barrot, M ;
Debonnel, G .
BIOLOGICAL PSYCHIATRY, 2005, 57 (08) :918-925
[10]   Serotonin4 (5-HT4) receptor Agonists are putative antidepressants with a rapid onset of action [J].
Lucas, Guillaume ;
Rymar, Vladimir V. ;
Du, Jenny ;
Mnie-Filali, Ouissame ;
Bisgaard, Christina ;
Manta, Stella ;
Lambas-Senas, Laura ;
Wiborg, Ove ;
Haddjeri, Nasser ;
Pineyro, Graciela ;
Sadikot, Abbas F. ;
Debonnel, Guy .
NEURON, 2007, 55 (05) :712-725
12