Development of off-the-shelf B7H3 chimeric antigen receptor NK cell therapeutic with broad applicability across many solid tumors.

被引：0
|
作者：
Bjordahl, Ryan [1 ]
Goulding, John [1 ]
Chu, Hui-Yi [1 ]
Cichocki, Frank [2 ]
Zorko, Nicholas [2 ]
Davis, Zachary [2 ]
Felices, Martin [2 ]
Garcia, Alex [1 ]
Gaidarova, Svetlana [1 ]
Yeh, Wen-I [1 ]
Lee, Tom T. [1 ]
Miller, Jeffrey S. [2 ]
Valamehr, Bahram [1 ]
机构：
[1] Fate Therapeutics Inc, San Diego, CA USA
[2] Univ Minnesota, Minneapolis, MN USA
来源：
CANCER RESEARCH | 2021年 / 81卷 / 13期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1539
引用
收藏
页数：2
相关论文
共 46 条
  • [1] TARGETING PAN-TUMOR ASSOCIATED ANTIGEN B7H3 VIA COMBINATION OF TRI-SPECIFIC KILLER ENGAGER AND OFF-THE-SHELF NK CELL THERAPY ENHANCES SPECIFICITY AND FUNCTION AGAINST A BROAD RANGE OF SOLID TUMORS
    Miller, Jeffrey
    Zorko, Nicholas
    Kodal, Behiye
    Davis, Zachary
    Lenvik, Alexander
    Lenvik, Todd
    Walker, Joshua
    Vallera, Daniel
    Gaidarova, Svetlana
    Garcia, Alejandro
    Lee, Tom
    Bjordahl, Ryan
    Valamehr, Bahram
    Cichocki, Frank
    Felices, Martin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A287 - A288
  • [2] Development of Off-The-Shelf Cellular Therapy Engineered with Novel MICA/B-Reactive Chimeric Antigen Receptor for Pan-Targeting of Solid Tumors
    Pribadi, Mochtar
    Chu, Helen
    Pan, Yijia
    Liu, Ellen
    Sikaroodi, Shohreh
    Dinella, Jason
    Wolchko, Dylan
    Huffman, Janel
    Blum, Robert
    Chang, Chia-Wei
    Lai, Yi-Shin
    Bjordahl, Ryan
    Lee, Tom T.
    Valamehr, Bahram
    MOLECULAR THERAPY, 2020, 28 (04) : 338 - 339
  • [3] Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting
    Grote, Stefan
    Mittelstaet, Joerg
    Baden, Caroline
    Chan, Kenneth Chun-Ho
    Seitz, Christian
    Schlegel, Patrick
    Kaiser, Andrew
    Handgretinger, Rupert
    Schleicher, Sabine
    ONCOIMMUNOLOGY, 2020, 9 (01):
  • [4] Adapter Chimeric Antigen Receptor (aCAR)-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Universal Tumor Targeting
    Grote, Stefan
    Seitz, Christian M.
    Diepold, Simon
    Buchner, Markus
    Baden, Caroline
    Malenke, Elke
    Dieckmann, Sophie Marie
    Schwaemmle, Hanna
    Mittelstaet, Joerg
    Kaiser, Andrew
    Schlegel, Patrick
    Handgretinger, Rupert
    Schleicher, Sabine
    BLOOD, 2018, 132
  • [5] B7-H3-Targeting Chimeric Antigen Receptors Epstein-Barr Virus-specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3-positive Solid Tumors
    Yeo, Siok Ping
    Kua, Lindsay
    Tan, Jin Wei
    Lim, Joanna Kristyn
    Wong, Fiona H. S.
    Santos, May Delos
    Poh, Chek Meng
    Goh, Angeline X. H.
    Koh, Xin Yu
    Zhou, Xiaohua
    Rajarethinam, Ravisankar
    Chen, Qingfeng
    Her, Zhisheng
    Horak, Ivan D.
    Low, Lionel
    Tan, Kar Wai
    CANCER RESEARCH COMMUNICATIONS, 2024, 4 (06): : 1410 - 1429
  • [6] Antitumor responses in gastric cancer by targeting B7H3 via chimeric antigen receptor T cells
    Fengqiang Sun
    Xiaomei Yu
    Ruixue Ju
    Zhanzhao Wang
    Yuhui Wang
    Cancer Cell International, 22
  • [7] Antitumor responses in gastric cancer by targeting B7H3 via chimeric antigen receptor T cells
    Sun, Fengqiang
    Yu, Xiaomei
    Ju, Ruixue
    Wang, Zhanzhao
    Wang, Yuhui
    CANCER CELL INTERNATIONAL, 2022, 22 (01)
  • [8] "Off-The-Shelf" allogeneic chimeric antigen receptor T-cell therapy for B-cell malignancies: current clinical evidence and challenges
    Mohty, Razan
    Lazaryan, Aleksandr
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [9] Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity
    Zhang, Congcong
    Oberoi, Pranav
    Oelsner, Sarah
    Waldmann, Anja
    Lindner, Aline
    Tonn, Torsten
    Wels, Winfried S.
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [10] Off-The-Shelf Epstein Barr Virus Specific T Cells Armored with B7-H3-Targeting Chimeric Antigen Receptors Is an Effective and Safe Tumor- Agnostic Therapy For B7-H3 Positive Solid Malignancies
    Yeo, Siok Ping
    Kua, Lindsay
    Tan, Jin Wei
    Lim, Joanna Kristyn
    Wong, Fiona
    Delos Santos, May
    Poh, Chek Meng
    Xh, Angeline Goh
    Koh, Xin Yu
    Zhou, Xiao Hua
    Rajarethinam, R.
    Chen, Qing Feng
    Her, Zhisheng
    Horak, Ivan D.
    Low, Lionel
    Tan, Kar Wai
    CANCER RESEARCH, 2024, 84 (08)
12345