The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

被引：29

作者：

Purzycka-Bohdan, Dorota ^{[1
]}

Nowicki, Roman J. ^{[1
]}

Herms, Florian ^{[2
,3
]}

Casanova, Jean-Laurent ^{[4
,5
,6
,7
,8
]}

Fouere, Sebastien ^{[2
,3
]}

Beziat, Vivien ^{[4
,5
,6
]}

机构：

[1] Med Univ Gdansk, Dept Dermatol Venereol & Allergol, PL-80214 Gdansk, Poland

[2] Univ Paris, St Louis Hosp, AP HP, Dept Dermatol, 1 Ave Claude Vellefaux, F-75010 Paris, France

[3] St Louis Hosp, AP HP, Ctr Genital & Sexually Transmitted Dis, F-75010 Paris, France

[4] Necker Hosp Sick Children, INSERM, Necker Branch, Lab Human Genet Infect Dis,UMR 1163, F-75015 Paris, France

[5] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY 10065 USA

[6] Univ Paris Cite, Imagine Inst, F-75015 Paris, France

[7] Necker Hosp Sick Children, AP HP, Dept Pediat, F-75015 Paris, France

[8] Howard Hughes Med Inst, New York, NY 10065 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 09期

基金：

美国国家卫生研究院;

关键词：

giant condyloma acuminatum; Buschke-Lowenstein tumor; human papillomavirus; immunodeficiency; genetics; HUMAN-PAPILLOMAVIRUS TYPE-6; SQUAMOUS-CELL CARCINOMA; UPSTREAM REGULATORY REGION; QUADRIVALENT HPV VACCINE; GENITAL WARTS; COMBINED IMMUNODEFICIENCY; SURGICAL-MANAGEMENT; NETHERTON SYNDROME; IMMUNE-DEFICIENCY; LOEWENSTEIN TUMOR;

D O I：

10.3390/ijms23094547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the role of underlying HPV infections, and human genetic and immunological determinants of BLT.

引用

页数：15

共 140 条

[61] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses [J].