Antiviral and antiphlogistic activities of Hamamelis virginiana bark

被引：52

作者：

Erdelmeier, CAJ ^{[1
]}

Cinatl, J ^{[1
]}

Rabenau, H ^{[1
]}

Doerr, HW ^{[1
]}

Biber, A ^{[1
]}

Koch, E ^{[1
]}

机构：

[1] UNIV JOHANN WOLFGANG GOETHE, DEPT VIROL, CTR HYG, CLIN JOHANN WOLFGANG GOETHE, D-60596 FRANKFURT, GERMANY

来源：

PLANTA MEDICA | 1996年 / 62卷 / 03期

关键词：

Hamamelis virginiana L; Hamamelidaceae; bark; ultrafiltration; proanthocyanidins; antiviral activity; HSV-1; antiphlogistic activity; antioxidant activity; alpha-glucosidase; human leukocyte elastase (HLE);

D O I：

10.1055/s-2006-957868

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A crude hydroalcoholic extract from Hamamelis virginiana bark was subjected to ultrafiltration (UF) with a cut-off limit of 3 kDa to obtain a higher and a lower molecular weight fraction. Characterisation of the fractions was attempted with TLC, HPLC, acidic hydrolysis, and chromatography over Sephadex LH-20. The UF-concentrate was shown to consist mainly of oligomeric to polymeric proanthocyanidins (PA). This fraction was found to exhibit significant antiviral activity against Herpes simplex virus type 1 (HSV-1). In addition, the UV-concentrate displayed radical scavenging properties, inhibited alpha-glucosidase as well as human leukocyte elastase (HLE), and exhibited strong antiphlogistic effects in the croton oil ear edema test in the mouse. With the exception of the antioxidant potential and the inhibition of HLE-action the lower molecular fraction possessed weaker activities and contained mainly hamamelitannin, catechin, and further, unidentified constituents.

引用

页码：241 / 245

页数：5

共 31 条

[1] PLANT ANTIVIRAL AGENTS .7. ANTIVIRAL AND ANTIBACTERIAL PROANTHOCYANIDINS FROM THE BARK OF PAVETTA-OWARIENSIS [J].