Internal initiation is a 50-end-independent mode of translation initiation engaged by many virus-and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry sites (IRESs), in the 50 untranslated region (UTR) of the respective transcripts. In this review we discuss recent structural insight into how established IRESs first capture and then manipulate the eukaryotic translation machinery through non-canonical interactions and by guiding the intrinsic conformational flexibility of the eukaryotic ribosome. Because IRESs operate with reduced complexity and constitute minimal systems of initiation, comparison with canonical initiation may allow common mechanistic principles of the ribosome to be delineated.
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Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Abeyrathne, Priyanka D.
Koh, Cha San
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Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, RNA Therapeut Inst, Worcester, MA USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Koh, Cha San
Grant, Timothy
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Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Grant, Timothy
Grigorieff, Nikolaus
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Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Grigorieff, Nikolaus
Korostelev, Andrei A.
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h-index: 0
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Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, RNA Therapeut Inst, Worcester, MA USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
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Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Monash Univ, Monash Bioinformat Platform, Melbourne, Vic 3800, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Archer, Stuart K.
Shirokikh, Nikolay E.
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Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Moscow Reg State Inst Humanities & Social Studies, Kolomna 140410, RussiaAustralian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Shirokikh, Nikolay E.
Beilharz, Traude H.
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h-index: 0
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Monash Univ, Monash Biomed Discovery Inst, Dev & Stem Cells Program, Melbourne, Vic 3800, Australia
Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
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Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Berry, Katherine E.
Waghray, Shruti
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Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Waghray, Shruti
Mortimer, Stefanie A.
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Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Mortimer, Stefanie A.
Bai, Yun
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Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Bai, Yun
Doudna, Jennifer A.
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Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
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Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Boerneke, Mark A.
Dibrov, Sergey M.
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Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Dibrov, Sergey M.
Gu, Jing
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Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Gu, Jing
Wyles, David L.
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Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Wyles, David L.
Hermann, Thomas
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Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Univ Calif San Diego, Ctr Drug Discovery Innovat, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
机构:
Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Abeyrathne, Priyanka D.
Koh, Cha San
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, RNA Therapeut Inst, Worcester, MA USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Koh, Cha San
Grant, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Grant, Timothy
Grigorieff, Nikolaus
论文数: 0引用数: 0
h-index: 0
机构:
Janelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
Grigorieff, Nikolaus
Korostelev, Andrei A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, RNA Therapeut Inst, Worcester, MA USAJanelia Res Campus, Howard Hughes Med Inst, Ashburn, VA 20147 USA
机构:
Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Monash Univ, Monash Bioinformat Platform, Melbourne, Vic 3800, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Archer, Stuart K.
Shirokikh, Nikolay E.
论文数: 0引用数: 0
h-index: 0
机构:
Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Moscow Reg State Inst Humanities & Social Studies, Kolomna 140410, RussiaAustralian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
Shirokikh, Nikolay E.
Beilharz, Traude H.
论文数: 0引用数: 0
h-index: 0
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Monash Univ, Monash Biomed Discovery Inst, Dev & Stem Cells Program, Melbourne, Vic 3800, Australia
Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, EMBL Australia Collaborating Grp, Canberra, ACT 2601, Australia
机构:
Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Berry, Katherine E.
Waghray, Shruti
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Waghray, Shruti
Mortimer, Stefanie A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Mortimer, Stefanie A.
Bai, Yun
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Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Bai, Yun
Doudna, Jennifer A.
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Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
机构:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Boerneke, Mark A.
Dibrov, Sergey M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Dibrov, Sergey M.
Gu, Jing
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h-index: 0
机构:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Gu, Jing
Wyles, David L.
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Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Wyles, David L.
Hermann, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
Univ Calif San Diego, Ctr Drug Discovery Innovat, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA