Ribosomal Chamber Music: Toward an Understanding of IRES Mechanisms

被引:62
作者
Yamamoto, Hiroshi [1 ,2 ,3 ,4 ]
Unbehaun, Anett [1 ,2 ,3 ,4 ]
Spahn, Christian M. T. [1 ,2 ,3 ,4 ]
机构
[1] Charite, Charitepl 1, D-10117 Berlin, Germany
[2] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany
[3] Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany
[4] Berlin Inst Hlth, Inst Med Phys & Biophys, Charitepl 1, D-10117 Berlin, Germany
关键词
HEPATITIS-C-VIRUS; EUKARYOTIC TRANSLATION INITIATION; CRICKET-PARALYSIS-VIRUS; MESSENGER-RNA TRANSLATION; METHIONINE-INDEPENDENT INITIATION; ENTRY SITE IRES; PROTEIN-SYNTHESIS; HCV-IRES; INTERNAL INITIATION; BINDING-PROTEIN;
D O I
10.1016/j.tibs.2017.06.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Internal initiation is a 50-end-independent mode of translation initiation engaged by many virus-and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry sites (IRESs), in the 50 untranslated region (UTR) of the respective transcripts. In this review we discuss recent structural insight into how established IRESs first capture and then manipulate the eukaryotic translation machinery through non-canonical interactions and by guiding the intrinsic conformational flexibility of the eukaryotic ribosome. Because IRESs operate with reduced complexity and constitute minimal systems of initiation, comparison with canonical initiation may allow common mechanistic principles of the ribosome to be delineated.
引用
收藏
页码:655 / 668
页数:14
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