The impact of chromosomal rearrangements on regulation of gene expression

被引：66

作者：

Harewood, Louise ^{[1
]}

Fraser, Peter ^{[1
]}

机构：

[1] Babraham Inst, Nucl Dynam Programme, Cambridge CB22 3AT, England

来源：

HUMAN MOLECULAR GENETICS | 2014年 / 23卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

FACIOSCAPULOHUMERAL MUSCULAR-DYSTROPHY; COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER VARIATION; LONG-RANGE INTERACTIONS; EWING SARCOMA-CELLS; TRANSCRIPTION FACTORIES; HUMAN-LYMPHOCYTES; AROMATASE GENE; ORGANIZATION; TERRITORIES;

D O I：

10.1093/hmg/ddu278

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects that coding region single-nucleotide polymorphisms or mutations have on gene expression have been well documented, predominantly owing to their association with disease. The effects of structural chromosomal rearrangements are also receiving increasing attention with the development of new techniques that allow accurate, high-resolution data, whether genomic interaction or transcriptome data, to be generated right down to the single-cell level. Over the past 18 months, these advances in experimental techniques have been used to further confirm and delineate the substantial effects that chromosome rearrangements can have on the regulation of gene expression and provide evidence of direct links between the two.

引用

页码：R76 / R82

页数：7

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