Interleukin (IL)-1 β, IL-6 and tumor necrosis factor in patients with seasonal flu

被引：0
|
作者：
Ramos, Jose M. [1 ,2 ,3 ]
Garcia-Navarro, Mar [1 ,2 ,3 ]
Moreno, Victoria [4 ,5 ]
Gonzalez-de-la-Aleja, Pilar [1 ,2 ,3 ]
Gimeno-Gascon, Adelina [3 ,6 ]
Merino, Esperanza [2 ,3 ,7 ]
Portilla, Joaquin [1 ,2 ,3 ,7 ]
机构：
[1] Alicante Univ, Gen Hosp, Dept Internal Med, C Pintor Baeza 12, Alicante 03010, Spain
[2] Miguel Hernandez Univ, Dept Clin Med, Alicante, Spain
[3] ISABIAL FISABIO, Alicante, Spain
[4] Miguel Hernandez Univ, Immunol Area, Dept Clin Med, Alicante, Spain
[5] Alicante Univ, Gen Hosp, ISABIAI FISABIO, Alicante, Spain
[6] Alicante Univ, Microbiol Serv, Gen Hosp, Alicante, Spain
[7] Alicante Univ, Infect Dis Unit, Gen Hosp, Alicante, Spain
来源：
REVISTA ESPANOLA DE QUIMIOTERAPIA | 2018年 / 31卷 / 06期
关键词：
Respiratory Tract Infections; Influenza; Human; Pneumonia; VIRUS; MONOCYTES;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Introduction. The role of tumor necrosis factor (TNF), interleukin (IL)-1 beta and IL-6 in the pathogenicity of seasonal flu is unknown. Methods. We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction). Results. Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza Conclusion. IL-6 levels were lower in adults with influenza.
引用
收藏
页码：542 / 545
页数：4
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