Rhodium-catalyzed annulation between 2-arylimidazo[1,2-a]pyridines and alkynes leading to pyrido[1,2-a]benzimidazole derivatives

被引：42

作者：

Peng, Haibo ^{[1
]}

Yu, Jin-Tao ^{[1
]}

Jiang, Yan ^{[1
]}

Wang, Lei ^{[1
]}

Cheng, Jiang ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 19期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; N BOND FORMATION; POLYSUBSTITUTED NAPHTHALENE DERIVATIVES; RH(III)-CATALYZED OXIDATIVE ANNULATION; INTERNAL ALKYNES; DIRECTING GROUP; SUBSTITUTED NAPHTHALENES; REGIOSELECTIVE SYNTHESIS; ISOQUINOLONE SYNTHESIS; MOLECULAR-OXYGEN;

D O I：

10.1039/c5ob00450k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed annulation between 2-arylimidazo[1,2-a] pyridines and alkynes was developed, leading to pyrido[1,2-a] benzimidazole derivatives in moderate to excellent yields. Notably, the ring C in pyrido[1,2-a] benzimidazole and the naphthalene framework were constructed consecutively, which provided a potential pathway leading to such a structure. This procedure tolerated chloro, bromo, cyano and methoxycarbonyl groups.

引用

页码：5354 / 5357

页数：4

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