Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

被引：42
作者：
Gavaldà, J [1 ]
Martín, MT [1 ]
López, P [1 ]
Gomis, X [1 ]
Ramírez, JL [1 ]
Rodríguez, D [1 ]
Len, O [1 ]
Puigfel, Y [1 ]
Ruíz, I [1 ]
Pahissa, A [1 ]
机构：
[1] Univ Autonoma Barcelona, Hosp Univ Valle Hebron, Div Infect Dis, Infect Dis Res Lab, E-08193 Barcelona, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 07期
关键词：
D O I：
10.1128/AAC.49.7.3028-3030.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.
引用
收藏
页码：3028 / 3030
页数：3
相关论文
共 19 条
  • [1] PROPHYLACTIC EFFICACY OF AEROSOLIZED LIPOSOMAL (AMBISOME) AND NON-LIPOSOMAL (FUNGIZONE) AMPHOTERICIN-B IN MURINE PULMONARY ASPERGILLOSIS
    ALLEN, SD
    SORENSEN, KN
    NEJDL, MJ
    DURRANT, C
    PROFFIT, RT
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (06) : 1001 - 1013
  • [2] Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal response
    Becker, MJ
    de Marie, S
    Fens, MHAM
    Hop, WCJ
    Verbrugh, HA
    Bakker-Woudenberg, IAJM
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (05) : 813 - 820
  • [3] Efficacy of prophylactic aerosol amphotericin B lipid complex in a rat model of pulmonary aspergillosis
    Cicogna, CE
    White, MH
    Bernard, EM
    Ishimura, T
    Sun, M
    Tong, WP
    Armstrong, D
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) : 259 - 261
  • [4] British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections
    Denning, DW
    Kibbler, CC
    Barnes, RA
    [J]. LANCET INFECTIOUS DISEASES, 2003, 3 (04) : 230 - 240
  • [5] Invasive aspergillosis
    Denning, DW
    [J]. CLINICAL INFECTIOUS DISEASES, 1998, 26 (04) : 781 - 803
  • [6] MEASUREMENT OF THE RESPIRATORY VOLUMES OF LABORATORY ANIMALS
    GUYTON, AC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1947, 150 (01): : 70 - 77
  • [7] Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis
    Herbrecht, R
    Denning, DW
    Patterson, TF
    Bennett, JE
    Greene, RE
    Oestmann, JW
    Kern, WV
    Marr, KA
    Ribaud, P
    Lortholary, O
    Sylvester, R
    Rubin, RH
    Wingard, JR
    Stark, P
    Durand, C
    Caillot, D
    Thiel, E
    Chandrasekar, PH
    Hodges, MR
    Schlamm, HT
    Troke, PF
    de Pauw, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (06) : 408 - 415
  • [8] Pharmacokinetic evaluation of amphotericin B in lung tissue: Lung lymph distribution after intravenous injection and airspace distribution after aerosolization and inhalation of amphotericin B
    Koizumi, T
    Kubo, K
    Kaneki, T
    Hanaoka, M
    Hayano, T
    Miyahara, T
    Okada, K
    Fujimoto, K
    Yamamoto, H
    Kobayashi, T
    Sekiguchi, M
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) : 1597 - 1600
  • [9] CHITIN ASSAY USED TO DEMONSTRATE RENAL LOCALIZATION AND CORTISONE-ENHANCED GROWTH OF ASPERGILLUS-FUMIGATUS MYCELIUM IN MICE
    LEHMANN, PF
    WHITE, LO
    [J]. INFECTION AND IMMUNITY, 1975, 12 (05) : 987 - 992
  • [10] Aspergillosis case - Fatality rate: Systematic review of the literature
    Lin, SJ
    Schranz, J
    Teutsch, SM
    [J]. CLINICAL INFECTIOUS DISEASES, 2001, 32 (03) : 358 - 366
12