Fibroblast growth factor receptor 2 gene (FGFR2) rs2981582T/C polymorphism and susceptibility to breast cancer in Saudi women

被引：3

作者：

AlRaddadi, Rawya Ibrahim Rabeh ^{[1
]}

Alamri, Razan Jamaan Nafaa ^{[1
]}

Shebli, Weam Talal Yehya ^{[1
]}

Fallatah, Emad Ibrahim Yagoub ^{[2
]}

Alhujaily, Ahmed Safar ^{[3
]}

Mohamed, Hiba Salaheldin ^{[1
,4
]}

Alotibi, Mohammad Kdaimes H. ^{[1
]}

机构：

[1] Taibah Univ, Coll Sci, Dept Biol, POB 344, Madinah, Saudi Arabia

[2] King Fahad Hosp, Dept Oncol, Madinah, Saudi Arabia

[3] King Fahad Hosp, Dept Pathol, Madinah, Saudi Arabia

[4] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

来源：

SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2021年 / 28卷 / 11期

关键词：

Gene; FGFR2; rs2981582; Breast cancer; Saudi Arabia; GENOME-WIDE ASSOCIATION; RISK; VARIANTS; LOCI;

D O I：

10.1016/j.sjbs.2021.07.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblast growth factor receptor 2 is a protein encoded by FGFR2 gene and plays an important role in cellular growth. This study was conducted to investigate a potential association of FGFR2 rs2981582 with breast cancer. DNA was obtained from 137 Formalin-fixed, paraffin-embedded tumors and 98 normal breast tissue samples. Genotypes were carried out with PCR-RFLP. The odds ratio and 95% confidence interval (CI) were used to evaluate the power of the associations. A significant association between FGFR2 rs2981582 C allele and susceptibility to breast cancer was found (p-value < 0.0001, Odds Ratio = 2.3, %95 CI (1.5-3.0). No significant differences in FGFR2 rs2981582 genotypes and alleles distribution among breast patients with different hormonal receptor status (p > 0.05) were detected. However, a significant difference was found in genotypes and alleles distribution in ER+, PR-and HER2 between breast cancer cases and controls. This study showed an association of FGFR2 rs2981582T/C with breast cancer in Saudi women, further large study is required to validate the results. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：6112 / 6115

页数：4

共 35 条

[1]

ADNANE J, 1991, ONCOGENE, V6, P659

[2] Molecular subtypes of breast carcinoma in Saudi Arabia A retrospective study [J].

Alnegheimish, Norah A. ;

Alshatwi, Razan A. ;

Alhefdhi, Reem M. ;

Arafah, Maha M. ;

AlRikabi, Ammar C. ;

Husain, Sufia .

SAUDI MEDICAL JOURNAL, 2016, 37 (05) :506-512

[3]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[4] FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness [J].

Campbell, Thomas M. ;

Castro, Mauro A. A. ;

de Santiago, Ines ;

Fletcher, Michael N. C. ;

Halim, Silvia ;

Prathalingam, Radhika ;

Ponder, Bruce A. J. ;

Meyer, Kerstin B. .

CARCINOGENESIS, 2016, 37 (08) :741-750

[5] Physical Activity Before, During, and After Chemotherapy for High-Risk Breast Cancer: Relationships With Survival [J].

Cannioto, Rikki A. ;

Hutson, Alan ;

Dighe, Shruti ;

McCann, William ;

McCann, Susan E. ;

Zirpoli, Gary R. ;

Barlow, William ;

Kelly, Kara M. ;

DeNysschen, Carol A. ;

Hershman, Dawn L. ;

Unger, Joseph M. ;

Moore, Halle C. F. ;

Stewart, James A. ;

Isaacs, Claudine ;

Hobday, Timothy J. ;

Salim, Muhammad ;

Hortobagyi, Gabriel N. ;

Gralow, Julie R. ;

Albain, Kathy S. ;

Budd, G. Thomas ;

Ambrosone, Christine B. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021, 113 (01) :54-63

[6] Associations of Polymorphisms in the Genes of FGFR2, FGF1, and RBFOX2 With Breast Cancer Risk by Estrogen/Progesterone Receptor Status [J].

Cen, Yu-Ling ;

Qi, Mei-Ling ;

Li, Hai-Gang ;

Su, Yi ;

Chen, Li-Juan ;

Lin, Ying ;

Chen, Wei-Qing ;

Xie, Xiao-Ming ;

Tang, Lu-Ying ;

Ren, Ze-Fang .

MOLECULAR CARCINOGENESIS, 2013, 52 :52-59

[7] TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk [J].

Chen, Ying ;

Shi, Chunying ;

Guo, Qiyong .

WORLD JOURNAL OF SURGICAL ONCOLOGY, 2016, 14

[8] GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients [J].

Cox, David G. ;

Curtit, Elsa ;

Romieu, Gilles ;

Fumoleau, Pierre ;

Rios, Maria ;

Bonnefoi, Herve ;

Bachelot, Thomas ;

Soulie, Patrick ;

Jouannaud, Christelle ;

Bourgeois, Hugues ;

Petit, Thierry ;

Tennevet, Isabelle ;

Assouline, David ;

Mathieu, Marie-Christine ;

Jacquin, Jean-Philippe ;

Lavau-Denes, Sandrine ;

Darut-Jouve, Ariane ;

Ferrero, Jean-Marc ;

Tarpin, Carole ;

Levy, Christelle ;

Delecroix, Valerie ;

Trillet-Lenoir, Veronique ;

Cojocarasu, Oana ;

Meunier, Jerome ;

Pierga, Jean-Yves ;

Faure-Mercier, Celine ;

Blanche, Helene ;

Sahbatou, Mourad ;

Boland, Anne ;

Bacq, Delphine ;

Besse, Celine ;

Deleuze, Jean-Francois ;

Pauporte, Iris ;

Thomas, Gilles ;

Pivot, Xavier .

ONCOTARGET, 2016, 7 (47) :77358-77364

[9] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[10] Polymorphisms in Second Intron of the FGFR2 Gene Are Associated with the Risk of Early-Onset Breast Cancer in Chinese Han Women [J].

Fu, Fangmeng ;

Wang, Chuan ;

Huang, Meng ;

Song, Chuangui ;

Lin, Shunguo ;

Huang, Heguang .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 226 (03) :221-229

← 1 2 3 4 →