Mesenchymal Stromal Cells: Potential Option for COVID-19 Treatment

被引：3

作者：

Primorac, Dragan ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Cemerin, Martin ^{[9
]}

Matisic, Vid ^{[1
]}

Molnar, Vilim ^{[1
]}

Strbad, Marko ^{[10
,11
]}

Girandon, Lenart ^{[10
]}

Zenic, Lucija ^{[12
]}

Knezevic, Miomir ^{[10
]}

Minger, Stephen ^{[13
]}

Polancec, Denis ^{[12
]}

机构：

[1] St Catherine Specialty Hosp, Zagreb 10000, Croatia

[2] Penn State Univ, Eberly Coll Sci, Univ Pk, State Coll, PA 16802 USA

[3] Univ New Haven, Henry C Lee Coll Criminal Justice & Forens Sci, West Haven, CT 06516 USA

[4] Univ Split, Med Sch, Split 21000, Croatia

[5] Josip Juraj Strossmayer Univ Osijek, Fac Dent Med & Hlth, Osijek 31000, Croatia

[6] Josip Juraj Strossmayer Univ Osijek, Fac Med, Osijek 31000, Croatia

[7] Univ Rijeka, Fac Med, Rijeka 51000, Croatia

[8] Med Sch REGIOMED, D-96450 Coburg, Germany

[9] Univ Zagreb, Sch Med, Zagreb 10000, Croatia

[10] Educell Ltd, Trzin 1236, Slovenia

[11] Biobanka Ltd, Trzin 1236, Slovenia

[12] Srebrnjak Childrens Hosp, Zagreb 10000, Croatia

[13] Natl Inst Biol, Ljubljana 1000, Slovenia

来源：

PHARMACEUTICS | 2021年 / 13卷 / 09期

关键词：

COVID-19; mesenchymal stromal cells; MSCs; immunomodulation; ARDS; UMBILICAL-CORD BLOOD; VERSUS-HOST-DISEASE; STEM-CELLS; BONE-MARROW; CYTOKINE STORM; FUNCTIONAL RECEPTOR; CORONAVIRUS; PATIENT;

D O I：

10.3390/pharmaceutics13091481

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The COVID-19 pandemic has significantly impacted the way of life worldwide and continues to bring high mortality rates to at-risk groups. Patients who develop severe COVID-19 pneumonia, often complicated with ARDS, are left with limited treatment options with no targeted therapy currently available. One of the features of COVID-19 is an overaggressive immune reaction that leads to multiorgan failure. Mesenchymal stromal cell (MSC) treatment has been in development for various clinical indications for over a decade, with a safe side effect profile and promising results in preclinical and clinical trials. Therefore, the use of MSCs in COVID-19-induced respiratory failure and ARDS was a logical step in order to find a potential treatment option for the most severe patients. In this review, the main characteristics of MSCs, their proposed mechanism of action in COVID-19 treatment and the effect of this therapy in published case reports and clinical trials are discussed.

引用

页数：14

共 103 条

[61] Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine [J].