Immunogenicity and safety of a combined diphtheria, tetanus, 5-component acellular pertussis, inactivated poliomyelitis, Haemophilus type b conjugate vaccine when administered concurrently with a pneumococcal conjugate vaccine: A randomized, open-label, phase 3 study

被引：6

作者：

Bernstein, Henry H. ^{[1
]}

Noriega, Fernando ^{[2
]}

机构：

[1] Childrens Hosp Dartmouth, Dartmouth Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pediat, Lebanon, NH 03756 USA

[2] Sanofi Pasteur Inc, Swiftwater, PA USA

来源：

VACCINE | 2011年 / 29卷 / 11期

关键词：

DTaP5-IPV-Hib vaccine (DTaP5-IPV/Hib); Pentacel; Pneumococcal vaccines; PENTAVALENT COMBINATION VACCINE; HEPATITIS-B; INFANTS; POLIO; HIB;

D O I：

10.1016/j.vaccine.2010.06.037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A phase 3 randomized, multicenter study evaluated the safety and immunogenicity of a combined diphtheria, tetanus, 5-component acellular pertussis, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccine (DTaP5-IPV/Hib) administered at the same visit with 7-valent pneumococcal conjugate vaccine (PCV7, concurrent group) or at separate visits (separated by >= 15 days; staggered group). DTaP5-IPV/Hib was administered at 2, 4, 6, and 15 months of age, and PCV7 was administered concurrently or at 3, 5, 7, and 16 months of age. The study results found that DTaP5-IPV/Hib is safe and immunogenic when given concurrently with 7-valent pneumococcal conjugate vaccine. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2212 / 2221

页数：10

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