Proteins: Sequence to Structure and Function - Current Status

被引:0
作者
Shenoy, Sandhya R.
Jayaram, B. [1 ]
机构
[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India
关键词
Sequence; structure; function; proteins; membrane; bioinformatics; prediction; metabolism; drug targets; disordered; flexibility; AMINO-ACID-SEQUENCE; ORTHOGONAL LATIN SQUARES; MONTE-CARLO SIMULATIONS; MULTIPLE-MINIMA PROBLEM; STRUCTURE PREDICTION; MEMBRANE-PROTEIN; TERTIARY STRUCTURES; EARLY EVENTS; TRANSMEMBRANE PROTEINS; CONFORMATIONAL SPACE;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In an era that has been dominated by Structural Biology for the last 30-40 years, a dramatic change of focus towards sequence analysis has spurred the advent of the genome projects and the resultant diverging sequence/structure deficit. The central challenge of Computational Structural Biology is therefore to rationalize the mass of sequence information into biochemical and biophysical knowledge and to decipher the structural, functional and evolutionary clues encoded in the language of biological sequences. In investigating the meaning of sequences, two distinct analytical themes have emerged: in the first approach, pattern recognition techniques are used to detect similarity between sequences and hence to infer related structures and functions; in the second ab initio prediction methods are used to deduce 3D structure, and ultimately to infer function, directly from the linear sequence. In this article, we attempt to provide a critical assessment of what one may and may not expect from the biological sequences and to identify major issues yet to be resolved. The presentation is organized under several subtitles like protein sequences, pattern recognition techniques, protein tertiary structure prediction, membrane protein bioinformatics, human proteome, protein-protein interactions, metabolic networks, potential drug targets based on simple sequence properties, disordered proteins, the sequence-structure relationship and chemical logic of protein sequences.
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收藏
页码:498 / 514
页数:17
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