Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum

被引：20
作者：
Zhao, Xi-Run [1 ]
Zhang, Bao-Jing [1 ]
Deng, Sa [1 ]
Zhang, Hou-Li [1 ]
Huang, Shan-Shan [1 ]
Huo, Xiao-Kui [1 ]
Wang, Chao [1 ,5 ]
Liu, Fang [2 ]
Ma, Xiao-Chi [1 ,3 ,4 ,5 ]
机构：
[1] Dalian Med Univ, Coll Pharm, Lvshun South Rd 9, Dalian 116044, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 2, Dalian 116044, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[4] Peking Union Med Coll, Beijing 100050, Peoples R China
[5] Dalian Med Univ, Liaoning Prov Key Lab Nat Prod Neurodegenerat Dis, Dalian 116044, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2016年 / 16卷
基金：
中国国家自然科学基金;
关键词：
Ganoderma lucidum; Lanostane; Triterpenoids; CYTOTOXICITY; DERIVATIVES; LEAVES; BIOTRANSFORMATION; POLYSACCHARIDE; SPORES;
D O I：
10.1016/j.phytol.2016.03.007
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1-4). Furthermore, in vitro bioassays using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and measuring the nitric oxide production in LPS-stimulated macrophages showed that the isolated triterpenoids had no inhibitory effects on p-glycoprotein (p-gp). (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：87 / 91
页数：5
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