Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum

被引：21

作者：

Zhao, Xi-Run ^{[1
]}

Zhang, Bao-Jing ^{[1
]}

Deng, Sa ^{[1
]}

Zhang, Hou-Li ^{[1
]}

Huang, Shan-Shan ^{[1
]}

Huo, Xiao-Kui ^{[1
]}

Wang, Chao ^{[1
,5
]}

Liu, Fang ^{[2
]}

Ma, Xiao-Chi ^{[1
,3
,4
,5
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Lvshun South Rd 9, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 2, Dalian 116044, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

[5] Dalian Med Univ, Liaoning Prov Key Lab Nat Prod Neurodegenerat Dis, Dalian 116044, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2016年 / 16卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma lucidum; Lanostane; Triterpenoids; CYTOTOXICITY; DERIVATIVES; LEAVES; BIOTRANSFORMATION; POLYSACCHARIDE; SPORES;

D O I：

10.1016/j.phytol.2016.03.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1-4). Furthermore, in vitro bioassays using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and measuring the nitric oxide production in LPS-stimulated macrophages showed that the isolated triterpenoids had no inhibitory effects on p-glycoprotein (p-gp). (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：87 / 91

页数：5

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