RETRACTED: Knockdown PEG10 deteriorates H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX (Publication with Expression of Concern. See vol. 141, pg. 346, 2022) (Retracted article. See vol. 144, pg. 178, 2022)

被引：5

作者：

Niu, Shizhen ^{[1
]}

Ni, Yong ^{[2
]}

Niu, Tong ^{[2
]}

Gao, Jianwen ^{[2
]}

机构：

[1] Jining Med Univ, Sch Clin Med, 16 Hehua Rd, Jining 272067, Shandong, Peoples R China

[2] Jining 1 PeopleS Hosp, Dept Spine Surg, Jining 272011, Shandong, Peoples R China

来源：

MOLECULAR IMMUNOLOGY | 2020年 / 118卷

关键词：

Spinal cord injury; lncRNA PEG10; miR-34a-5p; TLX; Smad and Wnt/beta-catenin pathways; SPINAL-CORD-INJURY; EXPRESSION; TLX; GENE;

D O I：

10.1016/j.molimm.2019.11.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective: Spinal cord injury (SCI) is a neurological disease with high incidence and disability. In this paper, we made a foundational study in long non-coding RNA paternally expressed gene 10 (lncRNA PEG10) at PC-12 cells. Methods: We used CCK8, flow cytometry, migration and invasion assay to detect changes at the cellular level. PEG10, microRNA-34a-5p (miR-34a-5p) and TLX transfected by transfection assay and amplified by real-time quantitative PCR (qRT-PCR). TLX expression and proteins about apoptosis and pathways were investigated by Western blot. Additionally, the relationship between PEG10 and miR-34a-5p, miR-34a-5p and TLX were examined through luciferase assay. Results: H2O2-injury model was established. Knockdown PEG10 deteriorated H2O2-injury. miR-34a-5p was confirmed as a target of PEG10 and miR-34a-5p inhibitor remitted PEG10-induced H2O2-injury. Moreover, TLX was confirmed as a target miR-34a-5p and TLX remitted H2O2-injury. At last, TLX worked in H2O2-injury via Smad and Wnt/beta-catenin pathways. Conclusion: Knockdown PEG10 remitted H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX, and the behavior may be involved in Smad and Wnt/beta-catenin pathways.

引用

页码：1 / 8

页数：8

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