CTRP3/cartducin promotes proliferation and migration of endothelial cells

被引：70
作者：
Akiyama, Hironori
Furukawa, Souhei
Wakisaka, Satoshi
Maeda, Takashi
机构：
[1] Osaka Univ, Grad Sch Dent, Dept Anat & Cell Biol, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Dent, Dept Radiol, Suita, Osaka 5650871, Japan
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2007年 / 304卷 / 1-2期
关键词：
CTRP3; cartducin; endothelial cells; proliferation; migration; MAPK;
D O I：
10.1007/s11010-007-9506-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
CTRP3/cartducin, a novel secretory protein, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. CTRP3/cartducin gene is transiently up-regulated in a balloon-injured rat carotid artery tissue. In this study, we report a new function of CTRP3/cartducin as a regulator of angiogenic processes. CTRP3/cartducin promoted proliferation and migration of mouse endothelial MSS31 cells in a dose-dependent manner. Further, stimulation of MSS31 by CTRP3/cartducin led to activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK). MAPK/ERK kinase 1/2 (MEK1/2) inhibitor, U0126, and p38 MAPK inhibitor, SB203580, blocked the CTRP3/cartducin-induced cell proliferation, and migration was blocked by U0126, but not the SB203580. Taken together, these results suggest that CTRP3/cartducin may be involved as a novel angiogenic factor in the formation of neointima following angioplasty.
引用
收藏
页码：243 / 248
页数：6
相关论文
共 21 条
[11]   Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes [J].
Maeda, T ;
Jikko, A ;
Abe, M ;
Yokohama-Tamaki, T ;
Akiyama, H ;
Furukawa, S ;
Takigawa, M ;
Wakisaka, S .
JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 206 (02) :537-544
[12]   Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development [J].
Maeda, T ;
Abe, M ;
Kurisu, K ;
Jikko, A ;
Furukawa, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (05) :3628-3634
[13]   CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion [J].
Mandal, Md Nawajes A. ;
Vasireddy, Vidyullatha ;
Reddy, G. Bhanuprakash ;
Wang, XiaoFei ;
Moroi, Sayoko E. ;
Pattnaik, Bikash R. ;
Hughes, Bret A. ;
Heckenlively, John R. ;
Hitchcock, Peter F. ;
Jablonski, Monica M. ;
Ayyagari, Radha .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (12) :5505-5513
[14]   Adventitial angiogenesis early after coronary angioplasty - Correlation with arterial remodeling [J].
Pels, K ;
Labinaz, M ;
Hoffert, C ;
O'Brien, ER .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (02) :229-238
[15]   Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase [J].
Rousseau, S ;
Houle, F ;
Kotanides, H ;
Witte, L ;
Waltenberger, J ;
Landry, J ;
Huot, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10661-10672
[16]   The role of mitogen-activated protein kinase activation within focal adhesions in chemotaxis toward FGF-2 by murine brain capillary endothelial cells [J].
Shono, T ;
Kanetake, H ;
Kanda, S .
EXPERIMENTAL CELL RESEARCH, 2001, 264 (02) :275-283
[17]   Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis [J].
Tanaka, K ;
Abe, M ;
Sato, Y .
JAPANESE JOURNAL OF CANCER RESEARCH, 1999, 90 (06) :647-654
[18]   Hypoxia-induced mitogenic factor enhances angiogenesis by promoting proliferation and migration of endothelial cells [J].
Tong, Qiangsong ;
Zheng, Liduan ;
Li, Bo ;
Wang, Danming ;
Huang, Chuanshu ;
Matuschak, George M. ;
Li, Dechun .
EXPERIMENTAL CELL RESEARCH, 2006, 312 (18) :3559-3569
[19]   A family of Acrp30/adiponectin structural and functional paralogs [J].
Wong, GW ;
Wang, J ;
Hug, C ;
Tsao, TS ;
Lodish, HF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) :10302-10307
[20]   Cloning of adiponectin receptors that mediate antidiabetic metabolic effects [J].
Yamauchi, T ;
Kamon, J ;
Ito, Y ;
Tsuchida, A ;
Yokomizo, T ;
Kita, S ;
Sugiyama, T ;
Miyagishi, M ;
Hara, K ;
Tsunoda, M ;
Murakami, K ;
Ohteki, T ;
Uchida, S ;
Takekawa, S ;
Waki, H ;
Tsuno, NH ;
Shibata, Y ;
Terauchi, Y ;
Froguel, P ;
Tobe, K ;
Koyasu, S ;
Taira, K ;
Kitamura, T ;
Shimizu, T ;
Nagai, R ;
Kadowaki, T .
NATURE, 2003, 423 (6941) :762-769
123