Epirubicin for breast cancer during pregnancy - A case report

被引：0
作者：
Eedarapalli, Padma
Biswas, Nibedan
Coleman, Matthew
机构：
[1] Poole Hosp NHS Trust, Dept Obstet & Gynecol, Poole BH15 2JB, Dorset, England
[2] Princess Anne Hosp, Dept Feto Maternal Med, Southampton, Hants, England
来源：
JOURNAL OF REPRODUCTIVE MEDICINE | 2007年 / 52卷 / 08期
关键词：
pregnancy complications; neoplastic; breast cancer; epirubicin; chemotherapy;
D O I：
暂无
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
BACKGROUND: The rarity of breast cancer in pregnancy and conflict between the optimal maternal therapy and fetal risks make its management challenging. Chemotherapy is the standard treatment for advanced cases. Epirubicin as a combination agent has been reported for breast and other cancers in pregnancy Nit not as a single agent. We report a case of advanced breast cancer treated with epirubicin neoadjuvant chemotherapy in pregnancy. CASE: A 30-year-old primigravida with multifocal, grade 3 invasive ductal carcinoma, stage T2 N1MO, reccived 4 cycles of primary epirubicin chemotherapy in pregnancy from 23 weeks' gestation. The chemotherapy was well tolerated by the mother and fetus, and a good response was achieved prior to postnatal combination chemotherapy and definitive surgery. CONCLUSION: Epirubicin chemotherapy appears safe and effective in pregnancy.
引用
收藏
页码：730 / 732
页数：3
相关论文
共 20 条
[1]  
Abe O, 1998, LANCET, V352, P930
[2]   Hematological malignancies and pregnancy:: A final report of 84 children who received chemotherapy in utero [J].
Avilés, A ;
Neri, N .
CLINICAL LYMPHOMA, 2001, 2 (03) :173-177
[3]   WEEKLY DOXORUBICIN CHEMOTHERAPY FOR BREAST-CANCER IN PREGNANCY - A CASE-REPORT [J].
BARNI, S ;
ARDIZZOIA, A ;
ZANETTA, G ;
STROCCHI, E ;
LISSONI, P ;
TANCINI, G .
TUMORI JOURNAL, 1992, 78 (05) :349-350
[4]   Management of breast cancer during pregnancy using a standardized protocol [J].
Berry, DL ;
Theriault, RL ;
Holmes, FA ;
Parisi, VM ;
Booser, DJ ;
Singletary, SE ;
Buzdar, AU ;
Hortobagyi, GN .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (03) :855-861
[5]   Deregulation of gene expression in fetal oocytes exposed to doxorubicin [J].
Bonilla, E ;
del Mazo, J .
BIOCHEMICAL PHARMACOLOGY, 2003, 65 (10) :1701-1707
[6]  
CUNNINGHAM FG, 2001, WILLIAMS OBSTETRICS, P1442
[7]  
Gadducci A, 2003, ANTICANCER RES, V23, P5225
[8]  
GALLIARD B, 1995, J GYNECOL OBST BIO R, V24, P63
[9]   Successful chemotherapy including epirubicin in a pregnant non-Hodgkin's lymphoma patient [J].
Goldwasser, F ;
Pico, JL ;
Cerrina, J ;
Fernandez, H ;
Pons, JC ;
Cosset, JM ;
Hayat, M .
LEUKEMIA & LYMPHOMA, 1995, 20 (1-2) :173-176
[10]  
GUINEE VF, 1994, LANCET, V343, P1587
12