共 47 条
The Prognostic Role of Ezrin and HER2/neu Expression in Osteosarcoma
被引:25
作者:

Abdou, Asmaa G.
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机构:
Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt

Kandil, Mona
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机构:
Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt

Asaad, Nancy Y.
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h-index: 0
机构:
Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt

Dawoud, Marwa M.
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h-index: 0
机构:
Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt

Shahin, Ahmed A.
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h-index: 0
机构:
Menofiya Univ, Fac Med, Dept Orthoped, Shebein Elkom 32511, Egypt Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt

Abd Eldayem, Amal F.
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h-index: 0
机构:
Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt
机构:
[1] Menofiya Univ, Fac Med, Dept Pathol, Shebein Elkom 32511, Egypt
[2] Menofiya Univ, Fac Med, Dept Orthoped, Shebein Elkom 32511, Egypt
关键词:
ezrin;
HER2/neu;
osteosarcoma;
prognosis;
GROWTH-FACTOR RECEPTOR;
HIGH-GRADE;
GENE-EXPRESSION;
CLINICAL-VALUE;
OVEREXPRESSION;
SURVIVAL;
IMMUNOEXPRESSION;
METAANALYSIS;
TRASTUZUMAB;
ASSOCIATION;
D O I:
10.1097/PAI.0000000000000197
中图分类号:
R602 [外科病理学、解剖学];
R32 [人体形态学];
学科分类号:
100101 ;
摘要:
Osteosarcoma is the most common primary malignant bone tumor in Egypt. Ezrin is involved in cell adhesion to the extracellular matrix and in cell-cell interactions facilitating metastasis. HER2/neu is overexpressed in breast cancer and other types of cancer. This study aimed to assess the expression of ezrin and HER2/neu in 57 primary osteosarcoma cases and to correlate their expression with the available clinicopathologic parameters and the overall, metastasis-free and event-free survival. Both ezrin and HER2/neu were not expressed in the normal bone and they were upregulated in 82.5% and 71.9% of osteosarcoma, respectively. Positive ezrin expression was significantly associated with young age (below 25 y) (P=0.01), high grade (P=0.001), and short survival time (P=0.0001). Positive HER2/neu expression was significantly associated with high-grade osteosarcoma (P=0.04). Membranous HER2/neu expression was the only factor that showed significant impact on metastasis-free (P=0.002) and event-free survival (P=0.002). Ezrin was significantly correlated with HER2/neu expression (P=0.02). Advanced stage (P=0.0001), metastasis (P=0.0001), and recurrence (P=0.01) were the factors affecting the overall survival of osteosarcoma patients. Ezrin and HER2/neu are overexpressed and coexpressed in osteosarcoma with adverse prognostic features such as high grade. Membranous pattern of HER2/neu seems to be more important than the cytoplasmic pattern because of its impact on metastasis-free and event-free survival. Therefore, ezrin and HER2/neu could be potential prognostic markers and treatment targets for osteosarcoma.
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收藏
页码:355 / 363
页数:9
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Goorin, Allen
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Boston, MA 02115 USA Massachusetts Gen Hosp, Dept Pediat Hematol Oncol, Boston, MA 02114 USA

Beardsley, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, New Haven, CT USA Massachusetts Gen Hosp, Dept Pediat Hematol Oncol, Boston, MA 02114 USA

Marina, Neyssa
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h-index: 0
机构:
Stanford Univ, Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA Massachusetts Gen Hosp, Dept Pediat Hematol Oncol, Boston, MA 02114 USA
[10]
Prognostic significance of rnrnunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma
[J].
Ferrari, Stefano
;
Zanella, Licciana
;
Alberghini, Marco
;
Palmerini, Emanuela
;
Staals, Eric
;
Bacchini, Patrizia
.
PEDIATRIC BLOOD & CANCER,
2008, 50 (04)
:752-756

Ferrari, Stefano
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy

Zanella, Licciana
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机构:
Ist Ortoped Rizzoli, Pathol Unit, Bologna, Italy Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy

Alberghini, Marco
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h-index: 0
机构:
Ist Ortoped Rizzoli, Pathol Unit, Bologna, Italy Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy

Palmerini, Emanuela
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h-index: 0
机构:
Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy

Staals, Eric
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Ortoped Rizzoli, Musculoskeletal Dept, Orthopaed Surg Unit, Bologna, Italy Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy

Bacchini, Patrizia
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Ortoped Rizzoli, Pathol Unit, Bologna, Italy Ist Ortoped Rizzoli, Chemotherapy Unit, I-40136 Bologna, Italy