A Review of Osteoporosis in the Older Adult: An Update

被引:60
作者
Alejandro, Paloma [1 ]
Constantinescu, Florina [1 ]
机构
[1] Georgetown Univ, Med Ctr, MedStar Washington Hosp Ctr, Div Rheumatol, 110 Irving St Northwest 2A-66, Washington, DC 20010 USA
关键词
Osteoporosis; Bisphosphonates; FRAX; Drug holiday; Hip fractures; Elderly; DXA; BONE-MINERAL DENSITY; ZOLEDRONIC ACID TREATMENT; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; FRACTURE RISK; VERTEBRAL FRACTURES; RANDOMIZED-TRIAL; ORAL IBANDRONATE; HIP FRACTURE; MEN;
D O I
10.1016/j.rdc.2018.03.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoporosis in the elderly population is common. It results in more than 1.5 million fractures per year in the United States. The goal of managing osteoporosis is to prevent fractures. In men, osteoporosis is underrecognized and undertreated. More men than women die every year as a consequence of hip fractures. Bisphosphonates are the first-line treatment of men and women. In the past several years, advances in bone biology have resulted in major therapeutic advances. This article reviews the diagnosis and treatment of osteoporosis.
引用
收藏
页码:437 / +
页数:16
相关论文
共 70 条
[21]   Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures - Results from the fracture intervention trial [J].
Cummings, SR ;
Black, DM ;
Thompson, DE ;
Applegate, WB ;
Barrett-Connor, E ;
Musliner, TA ;
Palermo, L ;
Prineas, R ;
Rubin, SM ;
Scott, JC ;
Vogt, T ;
Wallace, R ;
Yates, AJ ;
LaCroix, AZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (24) :2077-2082
[22]   Goal-directed treatment of osteoporosis [J].
Cummings, Steven R. ;
Cosman, Felicia ;
Eastell, Richard ;
Reid, Ian R. ;
Mehta, Mona ;
Lewiecki, E. Michael .
JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28 (03) :433-438
[23]   Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk [J].
Cummings, Steven R. ;
Tice, Jeffrey A. ;
Bauer, Scott ;
Browner, Warren S. ;
Cuzick, Jack ;
Ziv, Elad ;
Vogel, Victor ;
Shepherd, John ;
Vachon, Celine ;
Smith-Bindman, Rebecca ;
Kerlikowske, Karla .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (06) :384-398
[24]   Incidence of Atypical Nontraumatic Diaphyseal Fractures of the Femur [J].
Dell, Richard M. ;
Adams, Annette L. ;
Greene, Denise F. ;
Funahashi, Tadashi T. ;
Silverman, Stuart L. ;
Eisemon, Eric O. ;
Zhou, Hui ;
Burchette, Raoul J. ;
Ott, Susan M. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (12) :2544-2550
[25]   Understanding the mechanisms of senile osteoporosis: New facts for a major geriatric syndrome [J].
Duque, Gustavo ;
Troen, Bruce R. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2008, 56 (05) :935-941
[26]   Effects of calcitriol or calcium on bone mineral density, bone turnover, and fractures in men with primary osteoporosis: A two-year randomized, double blind, double placebo study [J].
Ebeling, PR ;
Wark, JD ;
Yeung, S ;
Poon, C ;
Salehi, N ;
Nicholson, GC ;
Kotowicz, MA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09) :4098-4103
[27]  
Eisman JA, 2008, J RHEUMATOL, V35, P488
[28]   Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene -: Results from a 3-year randomized clinical trial [J].
Ettinger, B ;
Black, DM ;
Mitlak, BH ;
Knickerbocker, RK ;
Nickelsen, T ;
Genant, HK ;
Christiansen, C ;
Delmas, PD ;
Zanchetta, JR ;
Stakkestad, J ;
Glüer, CC ;
Krueger, K ;
Cohen, FJ ;
Eckert, S ;
Ensrud, KE ;
Avioli, LV ;
Lips, P ;
Cummings, SR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (07) :637-645
[29]   Bisphosphonates for Osteoporosis [J].
Favus, Murray J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (21) :2027-2035
[30]   The near absence of osteoporosis treatment in older men with fractures [J].
Feldstein, AC ;
Nichols, G ;
Orwoll, E ;
Elmer, PJ ;
Smith, DH ;
Herson, M ;
Aickin, M .
OSTEOPOROSIS INTERNATIONAL, 2005, 16 (08) :953-962