Tumor metabolic reprogramming in lung cancer progression

被引：35

作者：

Li, Xin ^{[1
,2
]}

Liu, Minghui ^{[1
,2
]}

Liu, Hongyu ^{[2
,3
]}

Chen, Jun ^{[1
,2
,3
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Dept Lung Canc Surg, Tianjin 300052, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Tianjin Lung Canc Inst, Tianjin Key Lab Lung Canc Metastasis & Tumor Micro, Tianjin 300052, Peoples R China

[3] Tianjin Med Univ, Gen Hosp, Tianjin Lung Canc Inst, Tianjin Key Lab Lung Canc Metastasis & Tumor Micro, 154 Anshan Rd, Tianjin 300052, Peoples R China

来源：

ONCOLOGY LETTERS | 2022年 / 24卷 / 02期

关键词：

metabolic reprogramming; lung cancer; ATP-CITRATE LYASE; FATTY-ACID SYNTHASE; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; PYRUVATE-KINASE; TCA CYCLE; IN-VITRO; RESISTANCE; PATHWAY; INHIBITION;

D O I：

10.3892/ol.2022.13407

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metabolic reprogramming is an important characteristic of tumor cells. Tumor cells reprogram their metabolic pathways to meet the material, energy and redox force needs for rapid proliferation. Metabolic reprogramming changes the level or type of specific metabolites inside and outside cells, and promotes tumor growth by affecting gene expression, cell state and the tumor microenvironment. Glucose metabolism, glutamine metabolism and lipid metabolism are significant metabolic pathways in tumors. Targeting metabolic reprogramming can significantly inhibit tumor growth and induce apoptosis. Metabolic reprogramming also plays an important role in maintaining the growth advantage of tumor cells and enhancing the chemotherapy tolerance of lung cancer. This review summarizes abnormal changes in the metabolism of glucose, fat and amino acids in lung cancer, and the underlying molecular mechanism, with the aim of providing novel ideas for the prevention, early diagnosis and treatment of lung cancer.

引用

页数：8

共 102 条

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