Adrenocortical tumors and insulin resistance: What is the first step?

被引：33

作者：

Altieri, Barbara ^{[1
]}

Tirabassi, Giacomo ^{[2
]}

Della Casa, Silvia ^{[1
]}

Ronchi, Cristina L. ^{[3
]}

Balercia, Giancarlo ^{[2
]}

Orio, Francesco ^{[4
,5
]}

Pontecorvi, Alfredo ^{[1
]}

Colao, Annamaria ^{[6
]}

Muscogiuri, Giovanna ^{[6
]}

机构：

[1] Catholic Univ, Div Endocrinol & Metab Dis, Inst Med Pathol, Rome, Italy

[2] Polytech Univ Marche, Umberto Hosp 1, Dept Clin & Mol Sci, Div Endocrinol, Ancona, Italy

[3] Univ Wurzburg, Univ Hosp, Dept Internal Med 1, Endocrine & Diabet Unit, D-97070 Wurzburg, Germany

[4] Parthenope Univ, Dept Sports Sci & Wellness, Naples, Italy

[5] Univ Hosp S Giovanni Di Dio E Ruggi Daragona, Dept Endocrinol & Diabetol, Fertil Tech Struct, Salerno, Italy

[6] Univ Naples Federico II, Endocrinol Sect, Dept Clin Med & Surg, Via Sergio Pasini 5, I-80121 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF CANCER | 2016年 / 138卷 / 12期

关键词：

adrenocortical tumor; insulin resistance; insulin receptor; IGF-1R; cortisol; GROWTH-FACTOR-I; NONFUNCTIONING ADRENAL INCIDENTALOMAS; SUBCLINICAL CUSHINGS-SYNDROME; FACTOR-BINDING PROTEIN-2; IGF-II; RECEPTOR ISOFORM; HYBRID RECEPTORS; GENE-EXPRESSION; BREAST-CANCER; FACTOR SYSTEM;

D O I：

10.1002/ijc.29950

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pathogenetic mechanisms underlying the onset of adrenocortical tumors (ACTs) are still largely unknown. Recently, more attention has been paid to the role of insulin and insulin-like growth factor (IGF) system on general tumor development and progression. Increased levels of insulin, IGF-1 and IGF-2 are associated with tumor cell growth and increased risk of cancer promotion and progression in patients with type 2 diabetes. Insulin resistance and compensatory hyperinsulinemia may play a role in adrenal tumor growth through the activation of insulin and IGF-1 receptors. Interestingly, apparently non-functioning ACTs are often associated with a high prevalence of insulin resistance and metabolic syndrome. However, it is unclear if ACT develops from a primary insulin resistance and compensatory hyperinsulinemia or if insulin resistance is only secondary to the slight cortisol hypersecretion by ACT. The aim of this review is to summarize the current evidence regarding the relationship between hyperinsulinemia and adrenocortical tumors.

引用

页码：2785 / 2794

页数：10

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