Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals

被引：127

作者：

Ahmad, Aftab ^{[1
]}

Yang, Wanwei ^{[2
]}

Chen, Guofang ^{[2
]}

Shafiq, Muhammad ^{[1
]}

Javed, Sundus ^{[1
]}

Zaidi, Syed Shujaat Ali ^{[1
]}

Shahid, Ramla ^{[1
]}

Liu, Chao ^{[2
]}

Bokhari, Habib ^{[1
]}

机构：

[1] COMSATS Univ, Dept Biosci, Islamabad, Pakistan

[2] Nanjing Univ Chinese Med, Jiangsu Prov Acad Tradit Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Endocrine & Diabet Ctr, Nanjing, Peoples R China

来源：

PLOS ONE | 2019年 / 14卷 / 12期

关键词：

METABOLIC-DISORDERS; INFLAMMATION; METAGENOME;

D O I：

10.1371/journal.pone.0226372

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type 2 diabetes mellitus (T2DM) accounts for 90% of diabetes cases worldwide. The majority of T2DM patients are obese. Dysbiosis in the gut microflora is strongly associated with the pathogenesis of obesity and T2DM; however, the microbiome of obese-T2DM individuals in the Pakistani population remains unexplored. The gut microbiota signature of 60 Pakistani adults was studied using 16S rRNA sequencing targeting V-3-V-4 hypervariable regions. The sequence analysis revealed that bacteria from Firmicutes were predominant along with those from Clostridia and Negativicutes, whereas bacteria from Verrucomicrobia, Bacteroidetes, Proteobacteria, and Elusimicrobia were less abundant among the obese T2DM patients. These data distinctively vary from those in reports on the Indian population. The difference in gut microbiota could presumably be related to the distinct lifestyle and eastern dietary habits (high carbohydrate and fat intake, low fiber intake) and unregulated antibiotic consumption. This is the first study carried out to understand the gut microbiome and its correlation with individual life style of obese T2DM patients in the Pakistani population.

引用

页数：15

共 53 条

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