Synthesis of a new chiral amino phosphine ligand and its application in the asymmetric allylic alkylation (AAA) reaction

被引：28

作者：

Feng, Jianqing ^{[1
]}

Bohle, D. Scott ^{[1
]}

Li, Chao-Jun ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.tetasy.2007.05.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This article describes the synthesis of a new chiral amino phosphine ligand based on an amino naphthol starting material, which is resolved efficiently by using L-tartaric acid. The asymmetric induction of the ligand in the Pd(0)-catalyzed allylic substitution of 1,3-diphenylprop-2-en-1-yl acetate with dimethyl malonate was investigated. Good yields and enantiomeric excesses up to 78% of the product were obtained. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1043 / 1047

页数：5

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