N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones

被引：23

作者：

Cheng, Jin-Tang ^{[1
]}

Chen, Xiang-Yu ^{[1
]}

Ye, Song ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Key Lab Mol Recognit & Funct, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 05期

基金：

美国国家科学基金会;

关键词：

DIELS-ALDER REACTIONS; TRICYCLIC-BETA-LACTONES; ASYMMETRIC-SYNTHESIS; TRIFLUOROMETHYL DIHYDROPYRANONES; DISUBSTITUTED KETENES; ENOLATE EQUIVALENTS; ALDOL-LACTONIZATION; 4+2 CYCLOADDITION; KETO ACIDS; DERIVATIVES;

D O I：

10.1039/c4ob02330g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of 2-aryl carboxylic acids and enones was developed, affording the corresponding chiral delta-lactones in good yields with good diastereo- and high enantioselectivities.

引用

页码：1313 / 1316

页数：4

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