In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults

被引：5

作者：

Roussotte, Florence F. ^{[1
]}

Siddarth, Prabha ^{[2
]}

Merrill, David A. ^{[2
]}

Narr, Katherine L. ^{[1
]}

Ercoli, Linda M. ^{[2
]}

Martinez, Jacqueline ^{[2
]}

Emerson, Natacha D. ^{[2
]}

Barrio, Jorge R. ^{[3
]}

Small, Gary W. ^{[2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Brain Mapping Ctr, Dept Neurol, 635 Charles E Young Dr South,NRB Suite 225, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, 635 Charles E Young Dr South,NRB Suite 225, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, 635 Charles E Young Dr South,NRB Suite 225, Los Angeles, CA 90095 USA

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2018年 / 26卷 / 01期

基金：

美国国家卫生研究院;

关键词：

FDDNP-PET; plaques; tangles; diastolic blood pressure; age-related cognitive decline; BETA-AMYLOID DEPOSITION; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; RISK-FACTORS; HYPERTENSION; IMPAIRMENT; DEMENTIA; TAU; NEUROPATHOLOGY; HOMOCYSTEINE;

D O I：

10.1016/j.jagp.2017.09.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: Growing evidence supports an association between increased blood pressure and: (a) poor cognitive performance in older adults, and (b) various biomarkers of increased Alzheimer's disease (AD) neuropathology. The objective of this study was to determine whether systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly associated with cognitive functioning in non-demented adults, and to examine in vivo AD pathology as a possible mediator of this association. Methods: Positron emission tomography (PET) scans with 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) provide in vivo measurements of plaque and tangle burden. A total of 101 non-demented older subjects with blood pressure data and FDDNP-PET scans were drawn from a larger study of predictors of cognitive decline. A neuropsychological test battery was used to compute "global cognitive scores" (averaged across five key domains), which served as an index of general cognitive functioning. Results: Higher DBP (but not SBP) was significantly associated with lower cognitive scores, controlling for age, sex, antihypertensive medication use, and ApoE genotype (eta(2) = 0.06). However, this relationship was no longer significant after introducing FDDNP-PET binding as an additional covariate in the statistical models. In vivo plaque and tangle burden accounted for over 30% of the observed association between higher DBP and poorer cognitive performance. Conclusions: By suggesting a mediation of the relationship between DBP and cognitive functioning by FDDNP-PET binding, this study advances our understanding of some potential predictors of cognitive decline in non-demented adults, and underscores the importance of devising early multimodal interventions to more effectively combat degenerative brain disorders.

引用

页码：13 / 22

页数：10

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