Assoication of XRCC1 gene polymorphisms with risk of non-small cell lung cancer

被引:0
作者
Kang, Shirong [1 ,2 ]
Ma, Ying [2 ]
Liu, Caixia [3 ]
Cao, Chunli [4 ]
Hanbateer [5 ]
Qi, Jiafeng [6 ]
Li, Jiwei [7 ]
Wu, Xu [7 ]
机构
[1] Southern Med Univ, Nanfang Hosp, Dept Thorac Surg, Guangzhou 510515, Guangdong, Peoples R China
[2] Inner Mongolia Med Coll, Affiliated Hosp, Dept Thorac Surg, Hohhot 010050, Peoples R China
[3] Inner Mongolia Med Coll, Affiliated Hosp, Dept Oncol, Hohhot 010050, Peoples R China
[4] Inner Mongolia Med Coll, Affiliated Hosp, Dept Digest, Hohhot 010050, Peoples R China
[5] Inner Mongolia Med Coll, Affiliated Peoples Hosp, Dept Thorac Surg, Hohhot 010050, Peoples R China
[6] Jiamusi Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Jiamusi 510515, Peoples R China
[7] Southern Med Univ, Nanfang Hosp, Dept Cardiothorac Surg, Guangzhou 510515, Guangdong, Peoples R China
关键词
XRCC1; polymorphism; non-small cell lung cancer; DNA-REPAIR GENES; ARG399GLN POLYMORPHISM; ARG194TRP POLYMORPHISM; NO ASSOCIATION; METAANALYSIS; SUSCEPTIBILITY; POPULATION; PROTEIN;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
DNA repair genes is a key factor for cancer susceptibility, and we conducted a case-control study to investigate the association of XRCC1 codons 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln) with risk of NSCLC. 210 NSCLC patients and 210 health control subjects were randomly selected from Huaihe Hospital between January 2012 and June 2014. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was taken to assess the genotyping of XRCC1 Arg194Trp, Arg280His and Arg399Gln. By multivariate logistic regression analysis, we found individuals carrying with Trp/Trp and Arg/Trp + Trp/Trp genotypes were associated with a significantly increased risk of NSCLC compared with Arg/Arg genotype, and the OR (95% CI) were 3.15 (1.32-8.09) and 1.52 (1.02-2.28), respectively. The potential association of Arg/Trp + Trp/Trp genotype of XRCC1 Arg194Trp with the risk of NSCLC is more evidence in smokers, and the OR (95% CI) was 1.78 (1.01-3.24). In conclusion, we found that XRCC1 Arg194Trp polymorphism may be associated with NSCLC risk, especially in smokers.
引用
收藏
页码:4171 / 4176
页数:6
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